What’s the fuss about linear dynamic range of detection for LC-MS/MS?

Aug 14, 2019 | Blogs, Technology | 0 comments

Well – all the fuss matters to us!

Accuracy and precision matter most when it comes to quantifying analytes in all sorts of sample matrices. And concentration ranges can vary widely, affecting the calibration range you choose for a particular assay. Which in turn, affects your sample prep and how you set up your experiment. So, the detection range of a mass spectrometer does matter and that matters to us here at SCIEX.

To maintain low assay detection limits, while being able to accurately quantitate across a wide sample concentration range, a mass spectrometer needs to have as wide a dynamic range as possible. In both the mid-range SCIEX TripleQuad 5500+ LC-MS/MS system – and high-end SCIEX TripleQuad 6500+ system, new detector technology can provide up to six orders of linear dynamic range (LDR) for broad quantitative coverage.1 Wider LDR means fewer sample dilutions are required, whilst maintaining assay sensitivity to reach your required limit of quantitation (LOQ). And ultimately – accurate, precise, and reproducible results.

How do we achieve it? Well, some say it’s magic, but it all comes down to physics! The clever scientists in the SCIEX R&D group in Toronto are continually innovating to meet the demands of the analytical science community. For both the SCIEX 5500+ and 6500+ systems, the detection technology combines a high energy dynode (HED) and multi-channel electron multiplier (CEM) that delivers up to 6 orders of LDR. For a variety of applications, such as pharmaceutical bioanalysis, trace contaminant detection in food and environmental samples, and clinical research assays, you can be sure that the detector in a SCIEX mass spectrometer is going to help deliver confident answers for those challenging assays associated with routine quantitation.

Need more convincing? Visit these pages to learn more about how improved LDR can help:


  1. Collins BA, Dima MA Ivosev G, Zhong F (2013) A high dynamic range pulse counting detection system for mass spectrometry. Rapid Comm Mass Spect 28(2), 209-216.

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Ashley Sage is the Senior Manager for Global Portfolio and Technology Strategic Marketing at SCIEX. He is responsible for looking after the strategic marketing campaigns for the product and technology portfolio. Most recently, Ashley was involved in the Generation Quant video creation and campaign. In his free time, Ashley enjoys golfing and spending time with his family.


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