GEN-MKT-18-7897-A
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SCIEX OS software can support external devices that are not under direct control by using contact closure. Contact closure enables synchronization of the SCIEX OS software controlled device (the MS) and the external device (the LC in this case), ensuring that experimental batches can be generated and run on the two devices with appropriate timing. For example, a sample batch can be developed in SCIEX OS software for MS acquisition, and then the same sample batch can be replicated on an external LC device with the desired methods and autosampler settings. With contact closure in place, acquisition of mass spectra will be triggered upon the start of the LC gradient method on the external device. This post will explain how to use contact closure to synchronize a NanoLC 425 system for nanoflow and microflow chromatography with a mass spectrometer controlled by SCIEX OS software.
Setting up the contact closure:
Setting up the MS system batch:
Setting up the LC system batch:
Viewing the pressure traces after acquisition is complete:
Starting acquisition:
RUO-MKT-18-11908-A
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