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Forensic

Forensic researches unravel the mysteries of a sample, what is the residue, what drugs were present? Get in-depth answers to your questions, answered by SCIEX experts and your peers.

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Maximize NPS analysis with accurate mass spectrometry

Maximize NPS analysis with accurate mass spectrometry

LC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many advantages, including the ability to reliably detect new drugs and their metabolites from a variety of biological matrices.

Unlock the benefits of nominal mass spectrometry for NPS analysis

Unlock the benefits of nominal mass spectrometry for NPS analysis

The development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and the quality of the results. They also need robust and sensitive instrumentation that can detect drugs at trace levels with high specificity, especially when it comes to novel psychoactive substances (NPS), which can be difficult to monitor and control.

The costly consequences of unplanned downtime

The costly consequences of unplanned downtime

Unplanned downtime is a formidable adversary that businesses across various industries strive to minimize. Defined as the unexpected interruption of regular operations, unplanned downtime can wreak havoc on productivity, profitability and customer satisfaction. In this article, we delve into the causes of unplanned downtime, its far-reaching consequences and strategies to mitigate its impact.

Analytical techniques for novel psychoactive substances (NPS) screening

Analytical techniques for novel psychoactive substances (NPS) screening

The increased prevalence of novel psychoactive substances (NPS) in the recreational drug market has been a major contributor to the ongoing opioid crisis. NPS are newly emerging compounds designed to mimic existing recreational drugs and have become potent alternatives to controlled opioids. They are also frequently used as adulterants or cutting agents for commonly abused drugs. Continuous abuse of these substances can result in severe intoxication and, in some cases, fatal overdose.

The age of novel psychoactive substances

The age of novel psychoactive substances

Novel psychoactive substances (NPS) are compounds designed to mimic existing recreational drugs. The emergence of NPS has changed the landscape of the synthetic drug market. While previously the market had a limited number of compounds belonging to a few chemical groups, with NPS it now has hundreds of compounds. The European Monitoring Center for Drugs and Drug Addiction is currently monitoring 730 substances, with more being identified each year.

Back to the new basics: Part 3 | LC vs. LC-MS and what it means for your lab

Back to the new basics: Part 3 | LC vs. LC-MS and what it means for your lab

In this final installment of our “Back to the new basics” series, we take one more look at analytical techniques and best practices in the lab, and opportunities to improve efficiency. Here, we explore the basic principles of high-performance liquid chromatography (LC) and liquid chromatography mass spectrometry (LC-MS), and how these techniques can affect a lab’s efficiency and productivity.

Cannabis, sports and the World Anti-Doping Agency

Cannabis, sports and the World Anti-Doping Agency

We’ve all heard about the doping scandal that shocked the cycling world at the 1998 Tour de France, right? Well, because of that scandal, the International Olympic Committee (IOC) arranged a World Conference on Doping that brought together all parties involved in the fight against doping. The Lausanne Declaration on Doping in Sport1 was adopted by the conference in February 1999 and included a call for an international anti-doping agency to be operational for the 2000 Olympics in Sydney. The World Anti-Doping Agency (WADA) was established in November 1999 to answer that call.

Back to the new basics: Part 2 | Do I need a single quadrupole or a triple quadrupole system?

Back to the new basics: Part 2 | Do I need a single quadrupole or a triple quadrupole system?

In this second installment of our 3-part “Back to the new basics” series, we continue to look at ways to improve lab productivity by using efficient techniques. The number of instrument options out there can be mind-boggling. Finding the right instrument—one that offers varying degrees of sensitivity, selectivity and specificity to meet your analytical needs—can be an intimidating challenge.

Back to the new basics: Part 3 | LC vs. LC-MS and what it means for your lab

Back to the new basics: Part 1 | Making the leap from GC-MS to LC-MS

Producing accurate results quickly in a demanding environment is no easy feat for analytical scientists. What’s more, many of us are constantly questioning ourselves—I certainly am—about whether we are employing the best technique for the analysis at hand.

It’s an overwhelming thought, considering the wide range of tools that are available to choose from, each of which offers varying levels of capacity, sensitivity, selectivity, specificity and cost. How do you meet the unique needs of your organization without breaking the bank? I get it, and I’m not here to convince you it’s easy. My aim is to guide you through the process to help you make the right decision for you.

What is variable window SWATH acquisition and why does it improve results quality?

What is variable window SWATH acquisition and why does it improve results quality?

To continue to improve the quality of the SWATH acquisition data that one can achieve in complex matrices, we are working on ways that we can decrease the size of the Q1 window, while still maintaining full mass range coverage and optimal cycle times.  One great way...

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