Why electron-activated dissociation (EAD) improves sequence variant analysis in biopharma LC/MS workflows by Roxana McCloskey | Apr 29, 2026 | Biopharma, BlogsIn biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
How NFD improves impurity detection and peak integration in CE SDS workflows by Roxana McCloskey | Apr 28, 2026 | Biopharma, BioPhase 8800 system, BlogsCE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
What´s new in SCIEX Now – spring release 2026 by Andrea Mueller | Apr 23, 2026 | Blogs, Service, Support, TrainingAt SCIEX, innovation doesn’t stop at instruments; it extends to how you interact with your LC-MS/MS or CE systems every day. That’s why we’re excited to introduce the SCIEX Now spring 2026 improvements: a set of meaningful enhancements shaped directly by your feedback.
The troubleshooting tool LC-MS users have been waiting for by Anja Pfenninger | Apr 23, 2026 | Blogs, Service, Support, TrainingIn today’s fast-paced analytical laboratories, uptime is not just important; it is mission-critical. Whether you are running high-throughput bioanalysis, environmental testing, or pharmaceutical workflows, every minute of LC-MS downtime can impact productivity, data quality, and timelines. That is why we are excited to introduce a smarter and faster way to troubleshoot.
Getting PFAS right: Why sample preparation matters by Sam Lodge | Apr 17, 2026 | Blogs, Environmental / Industrial, Food / BeverageUltra‑low reporting limits, expanding target lists, and the constant risk of background contamination mean that even small missteps before injection can compromise data integrity. PFAS can be introduced at nearly every stage of prep, from sampling containers and PPE to SPE cartridges, filters, solvents, and lab consumables, making contamination control as critical as analyte recovery.
CE‑SDS in monoclonal antibody therapeutic development by Roxana McCloskey | Mar 31, 2026 | Biopharma, BioPhase 8800 system, BlogsIn monoclonal antibody (mAb) development, assessment of purity and integrity of the protein in question is critical. CE‑SDS is the gold standard assay and is routinely run from analytical development through QC and lot release. It’s trusted because it consistently delivers quantitative, size‑based insight into purity and fragmentation, and it fits naturally into regulated environments.
EAD vs. ETD: Choosing the right fragmentation technique for small molecule Met ID studies by Kirsten Craven | Mar 25, 2026 | Blogs, PharmaIn drug discovery and development, Metabolite Identification (Met ID) plays a critical role in understanding biotransformation pathways, ensuring safety, and meeting regulatory requirements. Advanced mass spectrometry techniques have revolutionized this process, particularly through electron-based fragmentation methods such as Electron Activated Dissociation (EAD) and Electron Transfer Dissociation (ETD). While both techniques leverage electron interactions to generate informative fragment ions, they differ significantly in mechanism, performance, and suitability for Met ID workflows.
Predictable uptime starts with a predictable service strategy by Andrea Mueller | Mar 18, 2026 | Biopharma, Blogs, Clinical, Environmental / Industrial, Food / Beverage, Forensic, Life Science Research, Pharma, Service, Support, TechnologyIn analytical laboratories, performance is not optional. Whether supporting regulated pharmaceutical workflows, high-throughput CRO operations, clinical reporting, or food and environmental testing, your mass spectrometry and capillary electrophoresis systems are critical to productivity, compliance, and scientific confidence.
Alkaloids in food: Why robust testing matters How SCIEX supports food safety laboratories by Michael Scherer | Mar 18, 2026 | Blogs, Food / BeverageNaturally occurring toxins are an unavoidable reality of today’s global food supply, and among them, alkaloids represent one of the most analytically challenging and safety‑critical compound classes. Produced by plants as natural defence mechanisms, alkaloids can unintentionally enter food through contamination, co‑harvesting, or adulteration, posing serious risks to consumer health and regulatory compliance.
PFAS in textiles: What laboratories are starting to uncover by Craig Butt | Feb 25, 2026 | Blogs, Environmental / IndustrialWaterproof jackets. Stain-resistant shoes. Easy-clean fabrics are marketed as “performance.” Behind those everyday claims sits a class of chemicals now reshaping regulation, brand accountability, and laboratory science: PFAS.