Lipid nanoparticles (LNPs) are widely used vehicles for mRNA-based therapeutics and vaccines. However, ionizable lipids used in LNPs can be susceptible to N-oxide impurities that can cause functional loss of the mRNA cargo.
Hardware
Learn more about the technology in your SCIEX systems, get in-depth answers about what goes on inside the technology from the experts.
Maximize NPS analysis with accurate mass spectrometry
LC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many advantages, including the ability to reliably detect new drugs and their metabolites from a variety of biological matrices.
Unlock the benefits of nominal mass spectrometry for NPS analysis
The development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and the quality of the results. They also need robust and sensitive instrumentation that can detect drugs at trace levels with high specificity, especially when it comes to novel psychoactive substances (NPS), which can be difficult to monitor and control.
Relative migration time
How do I set up my processing method to calculate the RRT of the main peak to 10kD in karat 32 software?
High mass tuning calibration for ZenoTOF 7600
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Adducts and N-oxides: understanding lipid nanoparticles (LNPs) for better mRNA drugs
Lipid nanoparticles (LNPs) are widely used vehicles for messenger RNA (mRNA)-based therapeutics and vaccines. However, ionizable lipids used in LNPs can be susceptible to N-oxide impurities that can cause functional loss of the mRNA cargo.
Metabolite identification and peace of mind
Managing metabolite identification (Met ID) studies is challenging, so what is at the top of your priority list as you plan the year ahead? Ensuring you have the data needed to manage product safety, meeting deadlines, staff recruitment and training, maintaining compliance, capital expenses, or something else?
Beyond mRNA: how advances in analytical techniques are enabling a revolution in the RNA drug landscape
Currently, there are 3 main types of in vitro transcribed (IVT) RNA drugs. Two of these—conventional messenger RNA (mRNA) and base-modified mRNA (bmRNA), which incorporates chemically modified nucleotides—are non-replicating. The third type is self-replicating RNA (srRNA), which is based on an engineered viral genome but devoid of viral structural protein genes. Its self-replicating ability makes srRNA a promising tool for new therapeutic drugs.
Changing the game of drug development with the Intabio ZT system
What better to learn how a new technology like icIEF-UV/MS is advancing drug development than hearing from the labs that are using it?
Data acquisition on the Echo® MS system: post-acquisition file splitting
The Echo® MS system is an ultra-high-throughput system that analyzes samples at a speed of up to 1 sample per second. To achieve fast acquisition speeds, MS data is collected for an entire batch—or the entire well plate—into a single experiment in a file....