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How do you protect the brand of your food testing lab and keep up with today’s global food safety standards? Join our community to learn about routine testing, advanced screening, and even method development. Cannabis regulations constantly evolve, pushing various limits from residue analysis, authenticity, potency, and quality control (QC). Keep abreast of the trends and discussions on new regulations and solutions with SCIEX experts and your peers.

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Rescheduling a Schedule I substance, and the Delta-8 controversy

Rescheduling a Schedule I substance, and the Delta-8 controversy

Did you know that in the US, drugs and other chemicals are classified into 5 distinct categories depending on the drug’s acceptable medical use and its potential for abuse or dependency?  Drugs federally classified as Schedule I substances by the US Drug Enforcement Administration (DEA) are considered to have the highest potential for abuse and for creating severe psychological and/or physical dependence. In addition to heroin, LSD and MDMA (ecstasy), cannabis is classified as a Schedule I substance in the Controlled Substance Act of 1970, which means it has no approved medical usage.

The pros and cons of using solid phase extraction and direct injection methods for PFAS testing

The pros and cons of using solid phase extraction and direct injection methods for PFAS testing

US Environmental Protection Agency (EPA) and Department of Defense (DoD) methods for testing per- and polyfluoroalkyl substances (PFAS) in drinking water require using solid phase extraction (SPE). SPE has been used extensively in environmental contaminant analysis both for concentrating large sample volumes (improving method sensitivity) and removing matrix interferences (sample cleanup).

What is variable window SWATH acquisition and why does it improve results quality?

What is variable window SWATH acquisition and why does it improve results quality?

To continue to improve the quality of the SWATH acquisition data that one can achieve in complex matrices, we are working on ways that we can decrease the size of the Q1 window, while still maintaining full mass range coverage and optimal cycle times.  One great way...

What is variable window SWATH acquisition and why does it improve results quality?

What is SWATH acquisition and what are the critical acquisition attributes?

In data-independent acquisition strategies like SWATH acquisition, an expanded mass isolation window is stepped across a mass range covering the mass-to-charge (m/z) distribution of peptides and a full scan MS/MS spectrum is collected at each step. Post-acquisition,...

High level method optimization considerations for Echo MS system

High level method optimization considerations for Echo MS system

While an in-depth discussion of method development and optimization for the Echo® MS system is beyond the scope of a community post, here are some points to consider as part of the process: The maximum recommended ion spray voltage for prolonged electrode life is 5000...

High level method optimization considerations for Echo MS system

What to do if you see peak shape deterioration or jagged peaks in your Echo MS system data?

Once a method has been developed, and good, consistent peak shapes have been obtained for an assay, the Echo® MS system is generally quite consistent. If peak quality deteriorates, consider the following points: The viscosity of the sample can affect the peak shape...

High level method optimization considerations for Echo MS system

Tips to maximize electrode lifetime for Echo MS system

While it’s easy to think of the Echo® MS system as an ultrafast LC system in front of the SCIEX Triple Quad 6500+ mass spectrometer, the system operates on fundamentally different principles. For this reason, it requires different routine maintenance to keep it...