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Rescheduling a Schedule I substance, and the Delta-8 controversy

Rescheduling a Schedule I substance, and the Delta-8 controversy

Did you know that in the US, drugs and other chemicals are classified into 5 distinct categories depending on the drug’s acceptable medical use and its potential for abuse or dependency?  Drugs federally classified as Schedule I substances by the US Drug Enforcement Administration (DEA) are considered to have the highest potential for abuse and for creating severe psychological and/or physical dependence. In addition to heroin, LSD and MDMA (ecstasy), cannabis is classified as a Schedule I substance in the Controlled Substance Act of 1970, which means it has no approved medical usage.

The pros and cons of using solid phase extraction and direct injection methods for PFAS testing

The pros and cons of using solid phase extraction and direct injection methods for PFAS testing

US Environmental Protection Agency (EPA) and Department of Defense (DoD) methods for testing per- and polyfluoroalkyl substances (PFAS) in drinking water require using solid phase extraction (SPE). SPE has been used extensively in environmental contaminant analysis both for concentrating large sample volumes (improving method sensitivity) and removing matrix interferences (sample cleanup).

What is variable window SWATH acquisition and why does it improve results quality?

What is variable window SWATH acquisition and why does it improve results quality?

To continue to improve the quality of the SWATH acquisition data that one can achieve in complex matrices, we are working on ways that we can decrease the size of the Q1 window, while still maintaining full mass range coverage and optimal cycle times.  One great way...

What is variable window SWATH acquisition and why does it improve results quality?

What is SWATH acquisition and what are the critical acquisition attributes?

In data-independent acquisition strategies like SWATH acquisition, an expanded mass isolation window is stepped across a mass range covering the mass-to-charge (m/z) distribution of peptides and a full scan MS/MS spectrum is collected at each step. Post-acquisition,...