To continue to improve the quality of the SWATH acquisition data that one can achieve in complex matrices, we are working on ways that we can decrease the size of the Q1 window, while still maintaining full mass range coverage and optimal cycle times. One great way...
Toxicology
Toxicology
What is SWATH acquisition and what are the critical acquisition attributes?
In data-independent acquisition strategies like SWATH acquisition, an expanded mass isolation window is stepped across a mass range covering the mass-to-charge (m/z) distribution of peptides and a full scan MS/MS spectrum is collected at each step. Post-acquisition,...
Having issues differentiating CBD from THC in hemp-derived products?
The popularity of CBD products has been on the rise following a federal move to legalize hemp. In an effort to regulate the sale of hemp-derived products in the United States, the government legalized CBD derived from hemp that contains no more than 0.3% THC by dry...
Need a reliable, crowd-sourced HR-MS database for screening Novel Psychoactive Substances (NPS)?
The recent influx of novel psychoactive substances (NPS) into the recreational drug market has posed a serious burden to public health. The availability of these substances through the Internet has contributed to the widespread of NPS globally, raising great concern...
Looking for an educational podcast on forensic toxicology?
Listen to the Toxpod, an informative podcast about the many facets of the field of forensic toxicology created by Tim Scott and Peter Stockham, two forensic toxicologists working for the South Australian government. Produced by Forensic Science South Australia and the...
Stay informed on the latest novel psychoactive substances (NPS) flooding the US drug market
Each year, the Drug Enforcement Administration (DEA) Special Testing and Research Laboratory publishes an Emerging Threat Report. The data contained in the report is updated quarterly and represents a snapshot of the drug evidence seized and analyzed by the DEA in the...
What is the Zeno threshold and what does it do?
With the introduction of the Zeno trap on the ZenoTOF 7600 system, sensitivity improvements on the order of 4 to 25x can be seen for MS/MS analysis, because of the optimization of duty cycle.1 When concentrations are low and peak intensities are limited, this bump in...