Christie Hunter on March 24, 2023 at 9:48 pm Hi Matt, There are ways to modify ProteinPilot software to incorporate new small molecule binders in your database search if you are using the desktop version of the software. With your software installer in documentation, there should be a document title “Advanced Configuration of ProteinPilot Software.pdf”. This walks you through how you can modify your Parameter Translation file to add new modifications (substitution sets) and modulate probabilities of binding and which residues they are likely to bind too. If you try this, make sure you save a backup of the original un-modified so you can always go back! Also, it is good to have a test dataset where you know the answer, to test that your modifications of the Parameter Translation file are doing what you expect. Also, our technical support team are very savvy on helping users with adapting the software for novel workflows, so feel free to reach out to support for help! Christie Log in to Reply
Matt Schnell on March 27, 2023 at 1:31 pm Thanks for the reply! Could you point me in the direction of the technical support? I’m having trouble finding it. Thanks! Log in to Reply