GEN-MKT-18-7897-A
Feb 13, 2020 | Blogs, Environmental / Industrial | 0 comments
The world of per- and polyfluoroalkyl substances (PFAS) research is a big one and one that’s currently front and center in environmental contamination concerns. Whether you work in industrial or academic environmental research, the issues surrounding these high-profile chemicals are of huge concern. How can your research, your lab group and your next grant proposal bring new knowledge to the state of the science?
Here, we look at some of the reasons why high-resolution tandem mass spectrometry (HRMS/MS) using the X500R QTOF System is ideal for labs at the cutting edge of PFAS research.
Are you a regulated testing lab? Find out why our nominal mass spectrometry solutions are best suited to your routine PFAS screening needs:
What analytical technology is best suited to the needs of a PFAS research lab?Over the years, interest has increased from just PFOS and PFOA to a small suite of perfluorinated carboxylates and sulfonates. Today, the scope of PFAS encompasses a far greater number of compounds, including so-called Gen-X chemicals, manufacturing byproducts, chemical precursors, potential degradation products, and more. Analysis of these emerging chemicals in a variety of environmental or even biological samples is vital for contribution to current research. Whether your challenge is characterizing their structures, determining their toxicity, evaluating their environmental fate, or understanding the impact of exposure, the need to detect, identify, and quantify PFAS is pivotal.
Expanding analytical capabilities to include HRMS/MS makes non-targeted screening methods for rapid PFAS detection and identification not only accessible but streamlined and achievable. The hybrid technology of quadruple time-of-flight (QTOF) system paired with liquid chromatography has been successfully employed in the discovery and research of environmental contaminants for decades.
The need for additional analytical functionality in leading environmental research labs is always evolving. Solutions capable of rapidly characterizing hundreds of unknown or suspect PFAS in a single run, even at trace levels, are no longer a fantasy. One comprehensive solution is the X500R QTOF System.
What are HRMS, QTOF, and LC?A few definitions:
Why is HRMS so powerful for researching PFAS?If you’re a PFAS researcher, you’d agree that PFAS research is complex. When identifying novel PFAS and metabolites in environmental samples, you are probably facing:
HRMS technology gives researchers the power to address these issues. By applying the advanced features and software workflows, researchers have access to screening, selectivity, and data processing capabilities to meet the modern needs of PFAS testing.
The X500R QTOF System solution: delivering the benefits to aid your PFAS screeningWhen you bring together the X500R QTOF System and an extensive PFAS MS/MS spectral library, great things happen. Here’s why:
Together, these features result in a platform with the speed and mass accuracy required for high-throughput, non-targeted PFAS characterization.
Are you a regulated testing lab? Find out why high-resolution mass spectrometry is a good system to have in your routine PFAS screening toolbox.
Access the X500R PFAS content pack which includes a webinar by Professor Christopher Higgins from the Colorado School of Mines.Download Your Content Pack >
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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