Take on New Analytical Challenges with the TripleTOF 6600 Accurate Mass System

Aug 25, 2017 | Blogs, Technology | 0 comments

Stay ahead of the curve by using the most advanced and versatile high-resolution accurate mass technology. The TripleTOF® 6600 accurate mass QTOF system can help you to analyze your samples faster, without compromising between speed, resolution, and sensitivity. Explore the technological advances that give this system the performance edge.

  1. Produce More Ions:  IonDrive™ Turbo V Source increases ion production by using enhanced gas flow dynamics and optimized heater configuration
  2. Capture More Ions: Qjet® Ion Guide provides large capture radius for efficient transfer of ions from source to quadrupole optics
  3. Focus More Ions: LINAC® collision cell provides high resolution through improved ion focusing, along with efficient and rapid ion transmission to  eliminate cross-talk and high duty cycle for maximum sensitivity
  4. Detect More Ions: Get 5-orders of linear dynamic range with the 4-channel MCP detector with ADC processing, which operates at low bias voltage to improve robustness and lifetime
  5. Resolve More Ions: Time-of-flight analyzer uses a 2-stage mirror and 15 kV acceleration to improve resolution and efficiency

In addition, you can get the flexibility your lab needs by configuring with nanoflow, microflow, conventional flow LC, or with capillary electrophoresis spray ionization (CESI) separation systems. And condensed data file sizes simplify and streamlines data storage and portability, without losses in data quality, completeness, or security.

Why SCIEX partners with experts around the world

Innovation in mass spectrometry does not happen in isolation. Some of the most impactful scientific advances emerge from highly specialized research communities – proteomics experts developing new peptide identification workflows, metabolomics researchers curating spectral databases, toxicologists building compound libraries, and biopharma scientists creating novel characterization methods.

Managing ADC characterization: The challenge of turning complexity into confidence

Unlike traditional monoclonal antibodies, ADCs combine an antibody backbone with linker chemistry and a cytotoxic payload. This multi-component architecture introduces overlapping layers of heterogeneity, including drug-to-antibody ratio (DAR) distributions, charge variants, post-translational modifications, and structural changes at both the intact and subunit levels. Across ADC development, these characteristics are considered critical quality attributes that must be characterized, understood, and monitored.

3 reasons ZT Scan DIA is changing the game in metabolomics

For years, metabolomics researchers have faced a frustrating reality: modern high-resolution mass spectrometers can detect tens of thousands of molecular features, yet only a fraction can be confidently identified. The challenge is no longer finding molecules. It is generating the high-quality MS/MS data needed to confidently assign structures and extract meaningful biological insights.

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