Technical notes using the Echo® MS+ system

Jun 17, 2025 | Blogs, Echo® MS+ system, Pharma | 0 comments

The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.

Download the technical notes below to learn more about this game-changing technology and the applications that can be conducted using the Echo® MS+ system.

Rapid MS/MS analysis with Acoustic Ejection Mass Spectrometry (AEMS). SCIEX technical note, RUO-MKT-02-11385-A
True high throughput bioanalysis using the Echo® MS System. SCIEX technical note, RUO-MKT-02-11649-A
Rapid quantitative analysis of fermentation broth samples to assess efficiency of engineered yeast strain turnover. SCIEX technical note, RUO-MKT-02-11695-A
Accelerating synthetic biology with very fast screening of metabolites in fermentation broth. SCIEX technical note, RUO-MKT-02-14011-A
Accelerated pharmacokinetic profiling and metabolite monitoring Using Echo® MS System. SCIEX technical note, RUO-MKT-02-12894-A
True high-throughput analysis of transporter activity screens. SCIEX technical note, RUO-MKT-02-13968-A
Ultra-fast quantification of alprazolam in human plasma extracts. SCIEX technical note, RUO-MKT-02-13059-A
High-throughput metabolite quantification for synthetic biology. SCIEX technical note, RUO-MKT-02-13362-A
Ultra-fast, accurate and simultaneous quantification of ritonavir and lopinavir in human plasma. SCIEX technical note, RUO-MKT-02-13058-A
Accelerating turnaround time in high-throughput ADME pipelines. SCIEX technical note, RUO-MKT-02-14235-B
Automating high-throughput ADME assays with LeadScape® 3.0 Analyze software on the Echo® MS system. SCIEX technical note, RUO-MKT-02-14841-A
Optimizing robustness for high-throughput screening on the Echo® MS+ system. SCIEX technical note, MKT- 31348-A
High-speed compound quality assessment using Acoustic Ejection Mass Spectrometry. SCIEX technical note, MKT-31143-A
High-throughput protein analysis using acoustic ejection mass spectrometry. SCIEX technical note, MKT- 31206-A
An automated, real-time measurement of kinetic hydrolysis of glucuronide using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-31227-A
Automated, rapid method optimization and buffer screening using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-30777-1
Determining optimal buffer concentration and compatibility for high-throughput intact protein analysis. SCIEX technical note, MKT-30944-A
High-resolution, specific analysis of arginine and citrulline on the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-27824-A
Rapid insulin analysis before-and-after TCEP reduction using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-27824-A
Rapid and accurate quantitation of thyroglobulin biomarkers using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-27824-A

The rules have changed

Regulated laboratories are evolving faster than ever. New analytical modalities, higher sample throughput, increasing regulatory scrutiny, and leaner teams are reshaping how work gets done. At the same time, expectations for data integrity, standardization, and operational efficiency continue to increase complexity and/or scope. In this environment, LC-MS software is no longer simply an instrument control platform—it has become a critical part of a laboratory’s quality management system. The question is no longer whether your lab has changed, but whether your software has evolved to support the way regulated labs operate today, and if they are ready and able to meet the demands, they will face tomorrow.

The wakeup call

Analyst software has long been a trusted foundation in regulated LC-MS laboratories—and for many, it still performs reliably today. But regulated environments are evolving faster than ever. As labs transition to Windows 11, strengthen cybersecurity policies, modernize IT infrastructure, and prepare for future compliance expectations, software decisions are no longer just about what works today—they’re about managing tomorrow’s risk. Analyst will not be supported on Windows 11. While some labs may continue operating in unsupported environments temporarily, the bigger question is: when that risk becomes reality, will your lab be reacting under pressure—or executing a planned mitigation strategy with confidence?

Why TFA in water Is gaining attention, and how labs can measure it with confidence

As regulatory scrutiny increases and detection requirements tighten, laboratories are facing a new question:
How can TFA be measured reliably, sensitively, and at scale?

Posted by

Anuja Bhalkikar

Anuja Bhalkikar is a Senior Scientist at SCIEX’s Echo® MS Center of Excellence. She supports the Echo® MS+ product line and is responsible for conducting customer demonstrations, providing technical support to clients that includes streamlining automation along with the EchoMS+ system, and generating new workflows. Anuja earned her Ph.D. in Chemistry from the University of Nebraska-Lincoln. She worked in a precision oncology clinical testing laboratory and the bioanalysis division at PPD a part of Thermo Fisher Scientific before joining SCIEX.

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