Anuja Bhalkikar

Technical notes using the Echo® MS+ system

Jun 17, 2025 | Blogs, Echo® MS+ system, Pharma | 0 comments

The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.

Download the technical notes below to learn more about this game-changing technology and the applications that can be conducted using the Echo® MS+ system.

Rapid MS/MS analysis with Acoustic Ejection Mass Spectrometry (AEMS). SCIEX technical note, RUO-MKT-02-11385-A
True high throughput bioanalysis using the Echo® MS System. SCIEX technical note, RUO-MKT-02-11649-A
Rapid quantitative analysis of fermentation broth samples to assess efficiency of engineered yeast strain turnover. SCIEX technical note, RUO-MKT-02-11695-A
Accelerating synthetic biology with very fast screening of metabolites in fermentation broth. SCIEX technical note, RUO-MKT-02-14011-A
Accelerated pharmacokinetic profiling and metabolite monitoring Using Echo® MS System. SCIEX technical note, RUO-MKT-02-12894-A
True high-throughput analysis of transporter activity screens. SCIEX technical note, RUO-MKT-02-13968-A
Ultra-fast quantification of alprazolam in human plasma extracts. SCIEX technical note, RUO-MKT-02-13059-A
High-throughput metabolite quantification for synthetic biology. SCIEX technical note, RUO-MKT-02-13362-A
Ultra-fast, accurate and simultaneous quantification of ritonavir and lopinavir in human plasma. SCIEX technical note, RUO-MKT-02-13058-A
Accelerating turnaround time in high-throughput ADME pipelines. SCIEX technical note, RUO-MKT-02-14235-B
Automating high-throughput ADME assays with LeadScape® 3.0 Analyze software on the Echo® MS system. SCIEX technical note, RUO-MKT-02-14841-A
Optimizing robustness for high-throughput screening on the Echo® MS+ system. SCIEX technical note, MKT- 31348-A
High-speed compound quality assessment using Acoustic Ejection Mass Spectrometry. SCIEX technical note, MKT-31143-A
High-throughput protein analysis using acoustic ejection mass spectrometry. SCIEX technical note, MKT- 31206-A
An automated, real-time measurement of kinetic hydrolysis of glucuronide using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-31227-A
Automated, rapid method optimization and buffer screening using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-30777-1
Determining optimal buffer concentration and compatibility for high-throughput intact protein analysis. SCIEX technical note, MKT-30944-A
High-resolution, specific analysis of arginine and citrulline on the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-27824-A
Rapid insulin analysis before-and-after TCEP reduction using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-27824-A
Rapid and accurate quantitation of thyroglobulin biomarkers using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-27824-A

Future-proofing pesticide testing: Why speed is becoming a competitive advantage

Food testing laboratories face growing pressure. Pesticide panels continue to expand, regulations evolve, and customers still expect fast turnaround times at a competitive cost.

Celebrating customer experience: Insights from SCIEX leaders

Customer Experience Day (CX Day) is a special occasion for SCIEX, celebrated every first Tuesday in October. It’s a day dedicated to recognizing the incredible value of our customers and the relentless dedication of our associates who strive to make every interaction meaningful. At SCIEX, our commitment to customer experience is woven into the fabric of everything we do. From providing cutting-edge solutions to offering unwavering support, we aim to build lasting relationships and exceed expectations. Join us as we delve into the insights from our leaders on what customer experience means to SCIEX and how it shapes our journey.

Why traditional MS/MS falls short for ADCs and how electron-activated dissociation (EAD) changes the equation

Antibody-drug conjugates (ADCs) are among the most promising—and analytically demanding—modalities in biopharma today. By combining large, heterogeneous antibodies with chemically labile payloads and linkers, ADCs introduce a level of structural complexity that challenges conventional analytical workflows. It also poses the challenge that the very features you need to measure are often the easiest to lose during analysis.

Posted by

Anuja Bhalkikar

Anuja Bhalkikar is a Senior Scientist at SCIEX’s Echo® MS Center of Excellence. She supports the Echo® MS+ product line and is responsible for conducting customer demonstrations, providing technical support to clients that includes streamlining automation along with the EchoMS+ system, and generating new workflows. Anuja earned her Ph.D. in Chemistry from the University of Nebraska-Lincoln. She worked in a precision oncology clinical testing laboratory and the bioanalysis division at PPD a part of Thermo Fisher Scientific before joining SCIEX.

0 Comments