Technical notes using the Echo® MS+ system

Jun 17, 2025 | Blogs, Echo® MS+ system, Pharma | 0 comments

The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.

Download the technical notes below to learn more about this game-changing technology and the applications that can be conducted using the Echo® MS+ system.

Rapid MS/MS analysis with Acoustic Ejection Mass Spectrometry (AEMS). SCIEX technical note, RUO-MKT-02-11385-A
True high throughput bioanalysis using the Echo® MS System. SCIEX technical note, RUO-MKT-02-11649-A
Rapid quantitative analysis of fermentation broth samples to assess efficiency of engineered yeast strain turnover. SCIEX technical note, RUO-MKT-02-11695-A
Accelerating synthetic biology with very fast screening of metabolites in fermentation broth. SCIEX technical note, RUO-MKT-02-14011-A
Accelerated pharmacokinetic profiling and metabolite monitoring Using Echo® MS System. SCIEX technical note, RUO-MKT-02-12894-A
True high-throughput analysis of transporter activity screens. SCIEX technical note, RUO-MKT-02-13968-A
Ultra-fast quantification of alprazolam in human plasma extracts. SCIEX technical note, RUO-MKT-02-13059-A
High-throughput metabolite quantification for synthetic biology. SCIEX technical note, RUO-MKT-02-13362-A
Ultra-fast, accurate and simultaneous quantification of ritonavir and lopinavir in human plasma. SCIEX technical note, RUO-MKT-02-13058-A
Accelerating turnaround time in high-throughput ADME pipelines. SCIEX technical note, RUO-MKT-02-14235-B
Automating high-throughput ADME assays with LeadScape® 3.0 Analyze software on the Echo® MS system. SCIEX technical note, RUO-MKT-02-14841-A
Optimizing robustness for high-throughput screening on the Echo® MS+ system. SCIEX technical note, MKT- 31348-A
High-speed compound quality assessment using Acoustic Ejection Mass Spectrometry. SCIEX technical note, MKT-31143-A
High-throughput protein analysis using acoustic ejection mass spectrometry. SCIEX technical note, MKT- 31206-A
An automated, real-time measurement of kinetic hydrolysis of glucuronide using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-31227-A
Automated, rapid method optimization and buffer screening using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-30777-1
Determining optimal buffer concentration and compatibility for high-throughput intact protein analysis. SCIEX technical note, MKT-30944-A
High-resolution, specific analysis of arginine and citrulline on the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-27824-A
Rapid insulin analysis before-and-after TCEP reduction using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-27824-A
Rapid and accurate quantitation of thyroglobulin biomarkers using the Echo® MS+ system with ZenoTOF 7600 system. SCIEX technical note, MKT-27824-A

Getting PFAS right: Why sample preparation matters

Ultra‑low reporting limits, expanding target lists, and the constant risk of background contamination mean that even small missteps before injection can compromise data integrity. PFAS can be introduced at nearly every stage of prep, from sampling containers and PPE to SPE cartridges, filters, solvents, and lab consumables, making contamination control as critical as analyte recovery.

CE‑SDS in monoclonal antibody therapeutic development

In monoclonal antibody (mAb) development, assessment of purity and integrity of the protein in question is critical. CE‑SDS is the gold standard assay and is routinely run from analytical development through QC and lot release. It’s trusted because it consistently delivers quantitative, size‑based insight into purity and fragmentation, and it fits naturally into regulated environments.

EAD vs. ETD: Choosing the right fragmentation technique for small molecule Met ID studies

In drug discovery and development, Metabolite Identification (Met ID) plays a critical role in understanding biotransformation pathways, ensuring safety, and meeting regulatory requirements. Advanced mass spectrometry techniques have revolutionized this process, particularly through electron-based fragmentation methods such as Electron Activated Dissociation (EAD) and Electron Transfer Dissociation (ETD). While both techniques leverage electron interactions to generate informative fragment ions, they differ significantly in mechanism, performance, and suitability for Met ID workflows.

Posted by

Anuja Bhalkikar

Anuja Bhalkikar is a Senior Scientist at SCIEX’s Echo® MS Center of Excellence. She supports the Echo® MS+ product line and is responsible for conducting customer demonstrations, providing technical support to clients that includes streamlining automation along with the EchoMS+ system, and generating new workflows. Anuja earned her Ph.D. in Chemistry from the University of Nebraska-Lincoln. She worked in a precision oncology clinical testing laboratory and the bioanalysis division at PPD a part of Thermo Fisher Scientific before joining SCIEX.

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