Analysis of chiral amphetamines using differential mobility separation (DMS) by Pierre Negri | Aug 7, 2021 | Data acquisition, Differential Mobility Separation (DMS), SCIEX information, TechnologyMany compounds are challenging to analyze because they are isomers (have the same m/z) and also sometimes have the same HPLC retention time. And to make it even more complicated, sometimes there are two chiral forms that have different functions in biology, making it...
Separating cyclosporin isomers using differential mobility separation (DMS) by Pierre Negri | Aug 7, 2021 | Data acquisition, Differential Mobility Separation (DMS), SCIEX information, TechnologyCyclosporin A (CsA) has been a very successful immunosuppressant for preventing organ transplant rejection. It is a large cyclic peptide (11 residues, ~1200 Da) and there are numerous modifications of this drug, some of which are isomers. The challenge of analyzing...
Innovation that’s blasting through limitations in explosive detection by Pierre Negri | Jul 10, 2020 | Blogs, ForensicMass spectrometry’s important role in identifying explosives The need for rapid explosive detection is now an unfortunate reality. The remit is multifaceted. The first is for preventative purposes, to protect us from any threat to life. The second is in the...
Keep up with fentanyl and its analogs: Failure to do so is not an option. by Pierre Negri | Feb 19, 2020 | Blogs, ForensicFentanyl is one of the most well-known synthetic opioids that has been in the spotlight lately—and not for good reasons. The World Drug Report 2019 reveals that there have been more than 47,000 opioid overdose deaths in the United States in 2017. This is an increase...
Mass spectrometry as a forensic science tool in 2020 by Pierre Negri | Jan 1, 2020 | Blogs, Forensic There’s no doubt about it: forensics is at the front line of the criminal justice system. It’s where analytical chemistry has the power to fight crimes. It’s fascinating! But what excites me is how quickly things change and the speed of innovation. Just think about...
Take 5 with SCIEX Global Technical Marketing’s Pierre Negri by Pierre Negri | Nov 25, 2019 | Blogs, ForensicWith the rise of Novel Psychoactive Substances (NPS), or designer drugs, in the past decade, forensic toxicologists are being tested like never before. It seems like as soon as one analog is identified, another is synthesized. These new chemicals share structures with...