Pure and simple: Understanding LNP analytics for better mRNA-based drugs by Kerstin Pohl | 0 CommentsA few years ago, it was discovered that messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNPs) could result in mRNA adducts due to the breakdown products of N-oxide impurities. The ionizable lipids used in LNPs are especially susceptible to forming N-oxide impurities.
Adducts and N-oxides: understanding lipid nanoparticles (LNPs) for better mRNA drugs by Kerstin Pohl | 0 CommentsLipid nanoparticles (LNPs) are widely used vehicles for messenger RNA (mRNA)-based therapeutics and vaccines. However, ionizable lipids used in LNPs can be susceptible to N-oxide impurities that can cause functional loss of the mRNA cargo.
Pure and simple: Understanding LNP analytics for better mRNA-based drugs by Kerstin Pohl | Biopharma, Blogs, ZenoTOF 7600 systemA few years ago, it was discovered that messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNPs) could result in mRNA adducts due to the breakdown products of N-oxide impurities. The ionizable lipids used in LNPs are especially susceptible to forming N-oxide impurities.
Adducts and N-oxides: understanding lipid nanoparticles (LNPs) for better mRNA drugs by Kerstin Pohl | Biopharma, Blogs, ZenoTOF 7600 systemLipid nanoparticles (LNPs) are widely used vehicles for messenger RNA (mRNA)-based therapeutics and vaccines. However, ionizable lipids used in LNPs can be susceptible to N-oxide impurities that can cause functional loss of the mRNA cargo.