Pure and simple: Understanding LNP analytics for better mRNA-based drugs by Kerstin Pohl | 0 CommentsA few years ago, it was discovered that messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNPs) could result in mRNA adducts due to the breakdown products of N-oxide impurities. The ionizable lipids used in LNPs are especially susceptible to forming N-oxide impurities.
Better mRNA-LNPs: encapsulation efficiency, mRNA integrity and purity, lipid N-oxides and beyond by Kerstin Pohl | 0 CommentsLipid nanoparticles (LNPs) are widely used vehicles for mRNA-based therapeutics and vaccines. However, ionizable lipids used in LNPs can be susceptible to N-oxide impurities that can cause functional loss of the mRNA cargo.
Adducts and N-oxides: understanding lipid nanoparticles (LNPs) for better mRNA drugs by Kerstin Pohl | 0 CommentsLipid nanoparticles (LNPs) are widely used vehicles for messenger RNA (mRNA)-based therapeutics and vaccines. However, ionizable lipids used in LNPs can be susceptible to N-oxide impurities that can cause functional loss of the mRNA cargo.
Handle with care: Ensuring LNP lipid quality for better genetic medicines by Matthew Stone | 0 CommentsLipid nanoparticles (LNPs) are widely used vehicles for oligonucleotide-based therapeutics and vaccines. However, LNPs can be susceptible to N-oxide-based impurities that can cause messenger RNA (mRNA) to lose function.
Pure and simple: Understanding LNP analytics for better mRNA-based drugs by Kerstin Pohl | Biopharma, Blogs, ZenoTOF 7600 systemA few years ago, it was discovered that messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNPs) could result in mRNA adducts due to the breakdown products of N-oxide impurities. The ionizable lipids used in LNPs are especially susceptible to forming N-oxide impurities.
Better mRNA-LNPs: encapsulation efficiency, mRNA integrity and purity, lipid N-oxides and beyond by Kerstin Pohl | Biopharma, BioPhase 8800 system, Blogs, ZenoTOF 7600 systemLipid nanoparticles (LNPs) are widely used vehicles for mRNA-based therapeutics and vaccines. However, ionizable lipids used in LNPs can be susceptible to N-oxide impurities that can cause functional loss of the mRNA cargo.
Adducts and N-oxides: understanding lipid nanoparticles (LNPs) for better mRNA drugs by Kerstin Pohl | Biopharma, Blogs, ZenoTOF 7600 systemLipid nanoparticles (LNPs) are widely used vehicles for messenger RNA (mRNA)-based therapeutics and vaccines. However, ionizable lipids used in LNPs can be susceptible to N-oxide impurities that can cause functional loss of the mRNA cargo.
Handle with care: Ensuring LNP lipid quality for better genetic medicines by Matthew Stone | Biopharma, Blogs, ZenoTOF 7600 systemLipid nanoparticles (LNPs) are widely used vehicles for oligonucleotide-based therapeutics and vaccines. However, LNPs can be susceptible to N-oxide-based impurities that can cause messenger RNA (mRNA) to lose function.