Elimination of Interference using the SelexION Differential Mobility System for the Quantitation of Rituximab in a Dual Surrogate Peptide Approach by SCIEX Community | Aug 22, 2017 | Biopharma, BlogsThe quantitation of proteins using the surrogate peptide approach can complicate nominal mass Triple Quadrupole MRM measurements due to co-extracted interference when using non-selective extraction techniques such as pellet digestion. High resolution coupled with...
Happy Birthday to SWATH Acquisition! 5 Years of Innovation by Christie Hunter | Aug 21, 2017 | Blogs, Life Science Research, Proteomics With its introduction at the HUPO World Congress in 2010 in Sydney Australia by Ruedi Aebersold, SWATH® Acquisition instantly intrigued scientists around the world. Here was a new technique with the potential to revolutionize the way proteomics studies were...
5 Tips for Calibrating a QTOF Mass Spectrometer by SCIEX Community | Aug 17, 2017 | Blogs, Life Science Research, Proteomics, TechnologyDo you have questions about your mass spec? How about a workflow? Our community members are involved in active discussions and receive expert answers from customers like you, SCIEX scientists, and support specialists every week. One recent topic concerned...
Enhancing In Vitro ADME Screening by SCIEX Community | Aug 14, 2017 | Blogs, PharmaDr. Graeme Clark, Head of Analytical Sciences, Cyprotex Discovery Ltd. LC-MS technology is helping contract research organization Cyprotex Discovery Ltd. perform bioanalysis of small molecules, peptides, and other pharmaceuticals, enabling quantification to be...
Host Cell Protein Analysis – Mass Spec’s Edge Over ELISA by SCIEX Community | Aug 11, 2017 | Biopharma, BlogsThe number of protein based drugs coming onto the market is at an all-time high, particularly those produced with a host cell system. With host cells come their own proteins. These host cell proteins (HCPs) constitute a major part of process-related impurities and can...