Stay informed on the latest novel psychoactive substances (NPS) flooding the US drug market by Pierre Negri | Aug 8, 2021 | Forensic, QTOF, QTRAP / Triple Quad, Results, SCIEX information, Toxicology, ZenoTOF 7600 systemEach year, the Drug Enforcement Administration (DEA) Special Testing and Research Laboratory publishes an Emerging Threat Report. The data contained in the report is updated quarterly and represents a snapshot of the drug evidence seized and analyzed by the DEA in the...
How does Collision Energy Spread work on the SCIEX QTOF, TripleTOF, and ZenoTOF systems? by Christie Hunter | Aug 8, 2021 | Data acquisition, QTOF, SCIEX information, Technology, ZenoTOF 7600 systemCollision energy spread (CES) generates a collision energy (CE) ramp around a collision energy center point, with the goal of providing a more, rich MS/MS spectrum of your analytes. The CE center point is either set in your acquisition method or computed on the fly...
How can I tell if my Spectral Peak is saturated on the TripleTOF system? by Christie Hunter | Aug 8, 2021 | Data acquisition, QTOF, SCIEX information, TechnologyThe key performance attributes for qualitative analysis are speed, mass accuracy, and resolution in both MS and MS/MS modes. For quantitative analysis, inter-scan dynamic range is important in order to maintain accuracy and linear response over a wide range of sample...
How does Dynamic Ion Transmission Control (DITC) work on the TripleTOF systems? by Christie Hunter | Aug 8, 2021 | Data acquisition, QTOF, SCIEX information, Technology, ZenoTOF 7600 systemDynamic Ion Transmission Control (ITC) is the feature on all the QTOF systems from SCIEX where the MS ion current through the instrument is modulated scan by scan to ensure the detector saturation point is not reached. The modulation is done both at the level of total...
What is the difference between MRM3 vs MS/MS/MS (MS3)? by Christie Hunter | Aug 8, 2021 | Data acquisition, QTRAP / Triple Quad, SCIEX information, TechnologyThe MRM3 workflow and the MS3 scan are functionally the same QTRAP system scan, but used with different goals in mind. The main difference is how these scans are used in the whole MS workflow. With MS3 scans, you can use these in a data dependent mode for discovery...