GEN-MKT-18-7897-A
Dec 23, 2025 | Blogs, Pharma, QTRAP / Triple Quad | 0 comments
Read time: 3 minutes
Investing in a new liquid chromatography-mass spectrometry (LC-MS) system is a big decision, especially when your lab handles a wide variety of analytical tasks. With so many options out there, it’s easy to feel overwhelmed.
That’s where this blog comes in. We’ll walk you through the bioanalytical quantitation solutions offered by SCIEX, helping you better understand which system might be the best fit for your current needs and future ambitions.
SCIEX doesn’t offer a one-size-fits-all approach. There are several LC-MS systems, each with its own strengths. So, whether you’re focused on today’s workflows or planning for tomorrow’s challenges, there’s a solution that aligns with your goals.
Let’s dig into this in more detail because life is never this simple.
Routine bioanalysis
When it comes to bioanalysis, SCIEX has been a trusted name in quadrupole mass spectrometry for as long as most of us can remember. But it’s not just about the hardware. We’re proud of the reliability, support, and innovation that come with every LC-MS system we offer.
All our instruments run on SCIEX OS software, a powerful yet intuitive platform designed to simplify your workflow. Whether you’re working in a regulated environment or not, using compliance-ready software from the start can be a smart move. It helps streamline method development and makes future transitions into regulated bioanalytical spaces smoother and faster.
Here is an example of the performance you can expect from the system, Highly sensitive LC-MS/MS method for the quantification of fluticasone propionate in human plasma using the SCIEX QTRAP 6500 System
Routine bioanalysis requiring higher sensitivity
As technology has developed, mass spectrometers have become more sensitive and what was considered a nice-to-have feature is now often essential. If you need to see trace-level analytes or your matrices are very complex, the 7500+ system is the better option for you.
Curious to see examples of what the 7500+ system can do?
Sensitive quantitation of glucagon-like peptide-1 (GLP-1) analog in rat plasma
Comprehensive LC-MS workflows for antibody drug conjugate (ADC) analysis
Flexible Quant/Qual system, more selectivity, or larger analytes
In the last 5 years, improvements in the quantitative performance and sensitivity of time-of-flight (TOF) technology has made it more attractive to bioanalysis labs. The ability to offer both quantitation and qualitative information on a single system makes life easier. Also, as drug modalities have changed and test compounds have become larger, they have exceeded the mass range of quadrupole systems making a TOF essential.
Additional benefits of a TOF are increased selectivity allowing low-level analytes to be distinguished from complex matrices. This can allow for shorter run times and reduced sample preparation.
Discover more about how the ZenoTOF 7600 could help in your lab, here:
Sensitive quantification of insulin lispro using accurate mass spectrometry (sciex.com)
High resolution LC-MS/MS solution for improved quantitation of peptides in a complex matrix
For more information on the options SCIEX has for bioanalysis please speak to your account manager or this technology pack may be of interest to you, New Frontiers in Bioanalysis.
Why not join the Mass spec bioanalysis community on LinkedIn?
The community offers the opportunity to:
Follow the link to join, here
Trifluoroacetic acid (TFA) is emerging as one of the most concerning ultrashort-chain PFAS in Europe’s food supply – particularly in cereals, a staple consumed daily by millions. A report from PAN Europe reveals a widespread and largely unmonitored contamination trend that raises serious questions about food safety, regulatory blind spots, and future monitoring strategies.
PFAS analysis is complex, but expert guidance doesn’t have to be. In this episode of our ‘Ask the PFAS expert series’, we’re joined by Michael Scherer, Application Lead for Food and Environmental, to answer the most pressing questions in PFAS analysis. From why LC-MS/MS systems are the gold standard for analyzing diverse PFAS compounds, to which EU methods deliver reliable results for drinking water, and to practical steps to prevent contamination, Michael shares actionable insights to help laboratories achieve accuracy, consistency, and confidence in their workflows.
During an LC-MS/MS experiment, traditional fragmentation techniques like collision-induced dissociation (CID) have long been the gold standard. Electron-activated dissociation (EAD) is emerging as a transformative tool that enhances structural elucidation, particularly for complex or labile metabolites.
Posted by
You must be logged in to post a comment.
Share this post with your network