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Dec 23, 2025 | Blogs, Pharma, QTRAP / Triple Quad | 0 comments
Read time: 3 minutes
Investing in a new liquid chromatography-mass spectrometry (LC-MS) system is a big decision, especially when your lab handles a wide variety of analytical tasks. With so many options out there, it’s easy to feel overwhelmed.
That’s where this blog comes in. We’ll walk you through the bioanalytical quantitation solutions offered by SCIEX, helping you better understand which system might be the best fit for your current needs and future ambitions.
SCIEX doesn’t offer a one-size-fits-all approach. There are several LC-MS systems, each with its own strengths. So, whether you’re focused on today’s workflows or planning for tomorrow’s challenges, there’s a solution that aligns with your goals.
Let’s dig into this in more detail because life is never this simple.
Routine bioanalysis
When it comes to bioanalysis, SCIEX has been a trusted name in quadrupole mass spectrometry for as long as most of us can remember. But it’s not just about the hardware. We’re proud of the reliability, support, and innovation that come with every LC-MS system we offer.
All our instruments run on SCIEX OS software, a powerful yet intuitive platform designed to simplify your workflow. Whether you’re working in a regulated environment or not, using compliance-ready software from the start can be a smart move. It helps streamline method development and makes future transitions into regulated bioanalytical spaces smoother and faster.
Here is an example of the performance you can expect from the system, Highly sensitive LC-MS/MS method for the quantification of fluticasone propionate in human plasma using the SCIEX QTRAP 6500 System
Routine bioanalysis requiring higher sensitivity
As technology has developed, mass spectrometers have become more sensitive and what was considered a nice-to-have feature is now often essential. If you need to see trace-level analytes or your matrices are very complex, the 7500+ system is the better option for you.
Curious to see examples of what the 7500+ system can do?
Sensitive quantitation of glucagon-like peptide-1 (GLP-1) analog in rat plasma
Comprehensive LC-MS workflows for antibody drug conjugate (ADC) analysis
Flexible Quant/Qual system, more selectivity, or larger analytes
In the last 5 years, improvements in the quantitative performance and sensitivity of time-of-flight (TOF) technology has made it more attractive to bioanalysis labs. The ability to offer both quantitation and qualitative information on a single system makes life easier. Also, as drug modalities have changed and test compounds have become larger, they have exceeded the mass range of quadrupole systems making a TOF essential.
Additional benefits of a TOF are increased selectivity allowing low-level analytes to be distinguished from complex matrices. This can allow for shorter run times and reduced sample preparation.
Discover more about how the ZenoTOF 7600 could help in your lab, here:
Sensitive quantification of insulin lispro using accurate mass spectrometry (sciex.com)
High resolution LC-MS/MS solution for improved quantitation of peptides in a complex matrix
For more information on the options SCIEX has for bioanalysis please speak to your account manager or this technology pack may be of interest to you, New Frontiers in Bioanalysis.
Why not join the Mass spec bioanalysis community on LinkedIn?
The community offers the opportunity to:
Follow the link to join, here
Regulated laboratories are evolving faster than ever. New analytical modalities, higher sample throughput, increasing regulatory scrutiny, and leaner teams are reshaping how work gets done. At the same time, expectations for data integrity, standardization, and operational efficiency continue to increase complexity and/or scope. In this environment, LC-MS software is no longer simply an instrument control platform—it has become a critical part of a laboratory’s quality management system. The question is no longer whether your lab has changed, but whether your software has evolved to support the way regulated labs operate today, and if they are ready and able to meet the demands, they will face tomorrow.
Analyst software has long been a trusted foundation in regulated LC-MS laboratories—and for many, it still performs reliably today. But regulated environments are evolving faster than ever. As labs transition to Windows 11, strengthen cybersecurity policies, modernize IT infrastructure, and prepare for future compliance expectations, software decisions are no longer just about what works today—they’re about managing tomorrow’s risk. Analyst will not be supported on Windows 11. While some labs may continue operating in unsupported environments temporarily, the bigger question is: when that risk becomes reality, will your lab be reacting under pressure—or executing a planned mitigation strategy with confidence?
As regulatory scrutiny increases and detection requirements tighten, laboratories are facing a new question: How can TFA be measured reliably, sensitively, and at scale?
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