GEN-MKT-18-7897-A
Jan 5, 2016 | Blogs, Forensic | 0 comments
What does every scientist think about in the lab? Validation. This is the feeling I encountered while reading a recent scientific report on nature.com. What struck me was not only the study itself which discounted cannabinoid incorporation into hair as a method for confirming consumption, but the test was carried out on the SCIEX QTRAP® 5500 linear ion-trap mass spectrometer. Here the authors produced a comprehensive LC-MS/MS study in which segmented hair samples (1 cm segments) were analyzed for THCA-A. Instead of using established GC/MS methods they were able to prove the validity of false positives as they applied to the presence of cannabinoids in hair samples.
Perhaps you have a study waiting to be published. Alternatively, maybe you are looking to push your lab into more extensive forensic testing this coming year. High-Resolution Accurate-Mass MS such as the X500R is proving to be the must-have instrument in every lab. However, how do you choose the right technology for your team? What is right for one lab is not the best option for another. Before you start spending, it is good to know some instruments come with way more technology than your lab might ever need while others are simply too routine. If you are in the market for mass spectrometry, here are some key points to remember:
The toolkit is loaded with research information including:
Forensic Toxicology Tests
The above article certainly brings into question the integrity of acquired results when challenged in the courtroom. If your lab is using old technology, we want to hear from you. Tell us what kind of experiments you are running and what are the setbacks you have encountered?
For research use only. Not for use in diagnostic procedures.
In drug discovery and development, Metabolite Identification (Met ID) plays a critical role in understanding biotransformation pathways, ensuring safety, and meeting regulatory requirements. Advanced mass spectrometry techniques have revolutionized this process, particularly through electron-based fragmentation methods such as Electron Activated Dissociation (EAD) and Electron Transfer Dissociation (ETD). While both techniques leverage electron interactions to generate informative fragment ions, they differ significantly in mechanism, performance, and suitability for Met ID workflows.
In analytical laboratories, performance is not optional. Whether supporting regulated pharmaceutical workflows, high-throughput CRO operations, clinical reporting, or food and environmental testing, your mass spectrometry and capillary electrophoresis systems are critical to productivity, compliance, and scientific confidence.
Naturally occurring toxins are an unavoidable reality of today’s global food supply, and among them, alkaloids represent one of the most analytically challenging and safety‑critical compound classes. Produced by plants as natural defence mechanisms, alkaloids can unintentionally enter food through contamination, co‑harvesting, or adulteration, posing serious risks to consumer health and regulatory compliance.
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