GEN-MKT-18-7897-A
Jan 5, 2016 | Blogs, Forensic | 0 comments
What does every scientist think about in the lab? Validation. This is the feeling I encountered while reading a recent scientific report on nature.com. What struck me was not only the study itself which discounted cannabinoid incorporation into hair as a method for confirming consumption, but the test was carried out on the SCIEX QTRAP® 5500 linear ion-trap mass spectrometer. Here the authors produced a comprehensive LC-MS/MS study in which segmented hair samples (1 cm segments) were analyzed for THCA-A. Instead of using established GC/MS methods they were able to prove the validity of false positives as they applied to the presence of cannabinoids in hair samples.
Perhaps you have a study waiting to be published. Alternatively, maybe you are looking to push your lab into more extensive forensic testing this coming year. High-Resolution Accurate-Mass MS such as the X500R is proving to be the must-have instrument in every lab. However, how do you choose the right technology for your team? What is right for one lab is not the best option for another. Before you start spending, it is good to know some instruments come with way more technology than your lab might ever need while others are simply too routine. If you are in the market for mass spectrometry, here are some key points to remember:
The toolkit is loaded with research information including:
Forensic Toxicology Tests
The above article certainly brings into question the integrity of acquired results when challenged in the courtroom. If your lab is using old technology, we want to hear from you. Tell us what kind of experiments you are running and what are the setbacks you have encountered?
For research use only. Not for use in diagnostic procedures.
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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