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The benefits of HRMS in discovery and development Q&A with Yves LeBlanc

HRMS offers considerable simplification of the analytical workflow to support discovery and development – a generic method that can be used across a broad range of samples with no tuning required. At the MS level, data can be interrogated in one of two ways: targeted data mining or untargeted. With accurate mass, one can either infer a chemical formula based on detected signal (untargeted) or simply mine the data for presence of specific compound (hypothesis driven – targeted analysis).Additional confirmation can also be extracted from the isotope pattern, thus providing confidence in the data interpretation. At the MSMS level, structural information can be extracted with higher confidence. HRMS has made automated data mining and interpretation far simpler to implement.

Rescheduling a Schedule I substance, and the Delta-8 controversy

Did you know that in the US, drugs and other chemicals are classified into 5 distinct categories depending on the drug’s acceptable medical use and its potential for abuse or dependency?  Drugs federally classified as Schedule I substances by the US Drug Enforcement Administration (DEA) are considered to have the highest potential for abuse and for creating severe psychological and/or physical dependence. In addition to heroin, LSD and MDMA (ecstasy), cannabis is classified as a Schedule I substance in the Controlled Substance Act of 1970, which means it has no approved medical usage.

sMRM Pro Builder template tutorial

The sMRM Pro Builder template is an Excel-based tool that can help you implement large panels of analytes in your lab. The Excel sheet will take your preliminary experimental results and compute retention times, retention time window widths and dwell time weighting to optimize your targeted assay.

The benefits of HRMS in discovery and development Q&A with Yves LeBlanc

The benefits of HRMS in discovery and development Q&A with Yves LeBlanc

HRMS offers considerable simplification of the analytical workflow to support discovery and development – a generic method that can be used across a broad range of samples with no tuning required. At the MS level, data can be interrogated in one of two ways: targeted data mining or untargeted. With accurate mass, one can either infer a chemical formula based on detected signal (untargeted) or simply mine the data for presence of specific compound (hypothesis driven – targeted analysis).Additional confirmation can also be extracted from the isotope pattern, thus providing confidence in the data interpretation. At the MSMS level, structural information can be extracted with higher confidence. HRMS has made automated data mining and interpretation far simpler to implement.

Rescheduling a Schedule I substance, and the Delta-8 controversy

Rescheduling a Schedule I substance, and the Delta-8 controversy

Did you know that in the US, drugs and other chemicals are classified into 5 distinct categories depending on the drug’s acceptable medical use and its potential for abuse or dependency?  Drugs federally classified as Schedule I substances by the US Drug Enforcement Administration (DEA) are considered to have the highest potential for abuse and for creating severe psychological and/or physical dependence. In addition to heroin, LSD and MDMA (ecstasy), cannabis is classified as a Schedule I substance in the Controlled Substance Act of 1970, which means it has no approved medical usage.

sMRM Pro Builder template tutorial

sMRM Pro Builder template tutorial

The sMRM Pro Builder template is an Excel-based tool that can help you implement large panels of analytes in your lab. The Excel sheet will take your preliminary experimental results and compute retention times, retention time window widths and dwell time weighting to optimize your targeted assay.