GEN-MKT-18-7897-A
Jun 17, 2026 | Blogs, Echo® MS+ system, Pharma, SCIEX OS software | 0 comments
Read time: 2 minutes
In this video, Daniel Collins, PhD, from Monash University shares how they are using LeadScape Optimize on the SCIEX OS platform at the Centre for Drug Candidate Optimisation, in Melbourne, Australia.
For more than 20 years, the CDCO has supported academic, commercial, and not‑for‑profit drug discovery programs with deep expertise in pharmaceutical lead optimization. Within the bioanalytical group, their role is to enable rapid and reliable decision‑making through quantitative analysis of candidate drugs in biological matrices.
As they have adopted acoustic ejection mass spectrometry using the Echo® MS system, the speed of sample analysis has increased dramatically. This shift has highlighted a new challenge, traditional manual MRM optimization can quickly become the bottleneck.
Daniel walks through how LeadScape Optimize helps address this issue by automating compound optimization and MRM generation directly within SCIEX OS software. This workflow reduces hands‑on analyst time, improves consistency, and enables us to keep pace with the throughput potential of Echo® MS system.
Practical examples from our Caco‑2 permeability assay, compare automated and guided optimization approaches, and highlight why this level of automation is becoming essential for modern lead optimization workflows.
Performance and benefits
Using the default settings, LeadScape Optimize performs a rapid positive and negative ion sweep before refining the optimal transitions. This process takes approximately four and a half minutes per compound, representing a modest time saving compared with guided MRM.
Where LeadScape truly excels, however, is in automation. The optimization runs without analyst intervention, freeing scientists to perform other tasks such as data review, method development on other instruments, or running parallel assays.
In direct comparisons, the MRMs generated by LeadScape were comparable to those derived from manual or guided optimization within SCIEX OS software. In our hands, the transitions were reliable, accurate, and well suited to quantitative Echo® MS system analyses.
Daniel explain how the CDCO, currently use LeadScape Optimize as a standalone MRM optimization tool for Echo® MS system‑based workflows, and it has already delivered significant benefits. As they move towards adopting the Analyse functionality more broadly, we expect these benefits to increase further.
Watch the full video here
In this interview, Andy Wilcox, Senior Market Development Manager, Aftermarket and Software, speaks with Susanna Baqué, Senior Director of Global Customer Experience, about how SCIEX Now gives customers one connected digital workspace to manage instruments, reduce time spent searching for information, resolve issues faster and keep their laboratory running more efficiently and with greater confidence.
As therapeutic pipelines continue to diversify, bioanalysis is being asked to do more than ever before. From small molecules to complex biologics, today’s scientists must generate high‑quality, reliable data across a growing range of molecule types and workflows, often under increasing time pressure.
Regulated laboratories are evolving faster than ever. New analytical modalities, higher sample throughput, increasing regulatory scrutiny, and leaner teams are reshaping how work gets done. At the same time, expectations for data integrity, standardization, and operational efficiency continue to increase complexity and/or scope. In this environment, LC-MS software is no longer simply an instrument control platform—it has become a critical part of a laboratory’s quality management system. The question is no longer whether your lab has changed, but whether your software has evolved to support the way regulated labs operate today, and if they are ready and able to meet the demands, they will face tomorrow.
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