GEN-MKT-18-7897-A
Sep 26, 2016 | Blogs, Environmental / Industrial | 0 comments
Pre-treatment versus direct injection – that is the question posed in the application note, “The Detection of Acidic Herbicides and Phenyl Ureas by LC-MS/MS with Large Volume Injection and Automated Column Switching.” It’s just one of the dozens of articles you will find within the Environmental Compendium (pages 1 to 4, pesticides) now available for download.Download Compendium >
Here’s the thing with Pesticides. They are taking a hit for their toxic pervasiveness to wildlife and suspected hormone-disrupting qualities. A problem as they find their way into drinking water via agriculture runoff or rogue dumping. This is not just in happening in Europe but the world over. However, since this particular report focuses on the UK, here is some background information on the state of water testing within the region. According to a Eurostat Report, seven percent of groundwater stations have reported excessive levels of one or more pesticides. However, as this application note points out, detection improvements are correlating with lowered acceptable limits. Hence, the need for a testing method that removes both cost and time associated with solid phase extraction and/or liquid/liquid extraction traditionally used for GC-MS analysis.
To give you an idea of what you will find not only in this study but throughout the environmental compendium, we’ve outlined some key points. For instance, you will discover how river and groundwater samples were obtained, filtered and directly injected into the LC-MS/MS system. Researchers thus follow up with graphics and content about:
Real-life scenarios and enforcing safety is a theme for the environmental compendium, and this application note demonstrates its effectiveness as the method is sensitive enough to be applied to U.K. surveillance work.
In drug discovery and development, Metabolite Identification (Met ID) plays a critical role in understanding biotransformation pathways, ensuring safety, and meeting regulatory requirements. Advanced mass spectrometry techniques have revolutionized this process, particularly through electron-based fragmentation methods such as Electron Activated Dissociation (EAD) and Electron Transfer Dissociation (ETD). While both techniques leverage electron interactions to generate informative fragment ions, they differ significantly in mechanism, performance, and suitability for Met ID workflows.
In analytical laboratories, performance is not optional. Whether supporting regulated pharmaceutical workflows, high-throughput CRO operations, clinical reporting, or food and environmental testing, your mass spectrometry and capillary electrophoresis systems are critical to productivity, compliance, and scientific confidence.
Naturally occurring toxins are an unavoidable reality of today’s global food supply, and among them, alkaloids represent one of the most analytically challenging and safety‑critical compound classes. Produced by plants as natural defence mechanisms, alkaloids can unintentionally enter food through contamination, co‑harvesting, or adulteration, posing serious risks to consumer health and regulatory compliance.
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