LC-MS/MS Screening of 64 New Psychoactive Substances Using Dried Blood Spots

Dec 16, 2016 | Blogs, Forensic | 0 comments

There is a lot you can tell from a droplet of blood as it’s snapshot of what could be present in a body at any given moment. In the following application note, LC-MS/MS Screening of 64 New Psychoactive Substances Using Dried Blood Spots, researchers did just that as they used dried blood spots (DBS) opposed to the more invasive venipuncture technique to detect 64 psychoactive substances in samples. 

To accomplish this research a highly sensitive QTRAP® LC-MS/MS was used in Multiple Reaction Monitoring (MRM) mode using the Scheduled MRM™ Algorithm. The importance of the method is that it can be expanded upon which is useful to government attempts at control the advent of new substances. When the European Monitoring System for Drugs and Addiction (EMCDDA) launched its Early Warning Program notification of new substances, for example, reported cases increased from 14 in 2008 to 98 in 2015.

As public awareness and government regulations like this become more profound, more accurate and less invasive testing methods are essential to keeping psychoactive substances off store shelves. In addition to sensitivity, the specimens can be easily stored, shipped, and maintained for future forensic testing.

Overcoming uncertainty in your PFAS analysis

Just like gum on the bottom of a shoe, the existence of per- and poly-fluorinated alkyl substances (PFAS) in our environment is a sticky one. If you’re in the field of environmental testing, then you’re all too familiar with the threat these substances have on public health. While we have learned a lot about them over the years, there is still much more to understand. With the right detection methods, we can gather the information we need to empower us to make informed decisions on reducing the risks they impose.

6 Signs it’s time for a new vendor

A lab’s success depends on many factors from instrument quality to efficient operations, including being partnered with the right vendor. A vendor is more than just a supplier. They should provide you with a high-level quality of support in maximizing the lifespan and performance of your systems, reducing downtime, enhancing ROI and more. How do you know if you’re partnered with the right one? Here are six signs it might be time to find someone new.

Plasmid manufacturing: Setting up your CGT programs for success

Plasmid DNA serves a variety of purposes, from critical starting material for proteins, mRNA, viral vectors, and drug substances. Below, Dr. Emma Bjorgum, the Vice President of Client Services of the DNA Business Unit at Aldevron and an expert in plasmid manufacturing, provided insights into the process and an outlook on the future.

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