GEN-MKT-18-7897-A
Dec 16, 2016 | Blogs, Forensic | 0 comments
There is a lot you can tell from a droplet of blood as it’s snapshot of what could be present in a body at any given moment. In the following application note, LC-MS/MS Screening of 64 New Psychoactive Substances Using Dried Blood Spots, researchers did just that as they used dried blood spots (DBS) opposed to the more invasive venipuncture technique to detect 64 psychoactive substances in samples.
To accomplish this research a highly sensitive QTRAP® LC-MS/MS was used in Multiple Reaction Monitoring (MRM) mode using the Scheduled MRM™ Algorithm. The importance of the method is that it can be expanded upon which is useful to government attempts at control the advent of new substances. When the European Monitoring System for Drugs and Addiction (EMCDDA) launched its Early Warning Program notification of new substances, for example, reported cases increased from 14 in 2008 to 98 in 2015.
As public awareness and government regulations like this become more profound, more accurate and less invasive testing methods are essential to keeping psychoactive substances off store shelves. In addition to sensitivity, the specimens can be easily stored, shipped, and maintained for future forensic testing.
It is no secret that (bio)pharmaceutical research and development is complex, both scientific and regulatory processes. Here is an overview of just some of the ways SCIEX is working to support these challenges.
In a recent webinar, available on demand, scientists Luiza Chrojan and Ryan Hylands from Pharmaron, provided insights into the deployment of capillary gel electrophoresis (CGE) within cell and gene therapy. Luiza and Ryan shared purity data on plasmids used for adeno-associated virus (AAV) manufacturing and data on AAV genome integrity, viral protein (VP) purity and VP ratios using the BioPhase 8800 system.
Last year, Technology Networks hosted two webinars that featured groundbreaking research utilizing SWATH DIA (data-independent acquisition) for exposomics and metabolomics. Researchers Dr. Vinicius Verri Hernandes from the University of Vienna and Dr. Cristina Balcells from Imperial College London (ICL) demonstrated how a DIA approach can be successfully implemented in small molecule analysis using the ZenoTOF 7600 system. Their innovative approaches highlight the potential of SWATH DIA to enhance the detection and analysis of chemical exposures and metabolites, paving the way for new insights into environmental health and disease mechanisms.
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