GEN-MKT-18-7897-A
Dec 16, 2016 | Blogs, Forensic | 0 comments
There is a lot you can tell from a droplet of blood as it’s snapshot of what could be present in a body at any given moment. In the following application note, LC-MS/MS Screening of 64 New Psychoactive Substances Using Dried Blood Spots, researchers did just that as they used dried blood spots (DBS) opposed to the more invasive venipuncture technique to detect 64 psychoactive substances in samples.
To accomplish this research a highly sensitive QTRAP® LC-MS/MS was used in Multiple Reaction Monitoring (MRM) mode using the Scheduled MRM™ Algorithm. The importance of the method is that it can be expanded upon which is useful to government attempts at control the advent of new substances. When the European Monitoring System for Drugs and Addiction (EMCDDA) launched its Early Warning Program notification of new substances, for example, reported cases increased from 14 in 2008 to 98 in 2015.
As public awareness and government regulations like this become more profound, more accurate and less invasive testing methods are essential to keeping psychoactive substances off store shelves. In addition to sensitivity, the specimens can be easily stored, shipped, and maintained for future forensic testing.
Waterproof jackets. Stain-resistant shoes. Easy-clean fabrics are marketed as “performance.” Behind those everyday claims sits a class of chemicals now reshaping regulation, brand accountability, and laboratory science: PFAS.
For decades, SCIEX has been part of bioanalytical innovation, empowering scientists in pharma and biopharma to push the boundaries of sensitivity, accuracy, and throughput. Across complex workflows and increasingly challenging therapeutic modalities.
Trifluoroacetic acid (TFA) is emerging as one of the most concerning ultrashort-chain PFAS in Europe’s food supply – particularly in cereals, a staple consumed daily by millions. A report from PAN Europe reveals a widespread and largely unmonitored contamination trend that raises serious questions about food safety, regulatory blind spots, and future monitoring strategies.
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