GEN-MKT-18-7897-A
Jan 29, 2023 | Biopharma, Blogs, Echo® MS+ system, Pharma | 1 comment
You asked, we answered! With analysis speeds of at least 1 sample per second, the Echo® MS system has created a buzz in the industry. This is up to 50x faster than conventional LC-MS/MS. This revolutionary tool for drug discovery and development has led to many questions from scientists and researchers around the world. We answer the top 7 Echo® MS system questions here.
The sample ejection volume for the Echo® MS system is about 0.1% of what you are injecting into an LC-MS system. Therefore, you are putting many fewer contaminants into the system over the same period of time.
The SCIEX OS software controls the system. This allows us to automatically process the data and export the results to any visualization software or LIMS. The SCIEX OS API (Application Programming Interface) allows integration with automation software from robotics vendors.
What types of liquid handling systems can be interfaced upstream of the Echo MS system? And what plate/sample throughput rates are possible?
The system is compatible with any vendor’s robotics system that can manage 384- and 1536-well plates. The cycle time for 384-well plates is less than 10 minutes, and for 1536-well plates it is less than 30 minutes.
The total size of the system is approximately 1.3 meters x 1.4 meters. This does not include the acquisition computer (which can be located up to 2 meters from the system) or the 1 meter of service access required around the entire system.
For a 384-well plate, the minimum volume required in the well is 20 µL and for 1536-well plates the minimum volume required is 3 µL. This is to ensure efficient ejection of the sample droplet.
Do you have a question? Please submit your question today or add it below in the comments.
Learn more about what the Echo® MS system can do for your lab at sciex.com/echoms. You will be able to see inside the system, download the brochure, gain access to technical notes, watch the video and request a quote.
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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