GEN-MKT-18-7897-A
Jan 29, 2023 | Biopharma, Blogs, Echo® MS+ system, Pharma | 1 comment
You asked, we answered! With analysis speeds of at least 1 sample per second, the Echo® MS system has created a buzz in the industry. This is up to 50x faster than conventional LC-MS/MS. This revolutionary tool for drug discovery and development has led to many questions from scientists and researchers around the world. We answer the top 7 Echo® MS system questions here.
The sample ejection volume for the Echo® MS system is about 0.1% of what you are injecting into an LC-MS system. Therefore, you are putting many fewer contaminants into the system over the same period of time.
The SCIEX OS software controls the system. This allows us to automatically process the data and export the results to any visualization software or LIMS. The SCIEX OS API (Application Programming Interface) allows integration with automation software from robotics vendors.
What types of liquid handling systems can be interfaced upstream of the Echo MS system? And what plate/sample throughput rates are possible?
The system is compatible with any vendor’s robotics system that can manage 384- and 1536-well plates. The cycle time for 384-well plates is less than 10 minutes, and for 1536-well plates it is less than 30 minutes.
The total size of the system is approximately 1.3 meters x 1.4 meters. This does not include the acquisition computer (which can be located up to 2 meters from the system) or the 1 meter of service access required around the entire system.
For a 384-well plate, the minimum volume required in the well is 20 µL and for 1536-well plates the minimum volume required is 3 µL. This is to ensure efficient ejection of the sample droplet.
Do you have a question? Please submit your question today or add it below in the comments.
Learn more about what the Echo® MS system can do for your lab at sciex.com/echoms. You will be able to see inside the system, download the brochure, gain access to technical notes, watch the video and request a quote.
Ultra‑low reporting limits, expanding target lists, and the constant risk of background contamination mean that even small missteps before injection can compromise data integrity. PFAS can be introduced at nearly every stage of prep, from sampling containers and PPE to SPE cartridges, filters, solvents, and lab consumables, making contamination control as critical as analyte recovery.
In monoclonal antibody (mAb) development, assessment of purity and integrity of the protein in question is critical. CE‑SDS is the gold standard assay and is routinely run from analytical development through QC and lot release. It’s trusted because it consistently delivers quantitative, size‑based insight into purity and fragmentation, and it fits naturally into regulated environments.
In drug discovery and development, Metabolite Identification (Met ID) plays a critical role in understanding biotransformation pathways, ensuring safety, and meeting regulatory requirements. Advanced mass spectrometry techniques have revolutionized this process, particularly through electron-based fragmentation methods such as Electron Activated Dissociation (EAD) and Electron Transfer Dissociation (ETD). While both techniques leverage electron interactions to generate informative fragment ions, they differ significantly in mechanism, performance, and suitability for Met ID workflows.
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