GEN-MKT-18-7897-A
Feb 16, 2017 | Blogs, Forensic | 0 comments
While most analytes in forensic applications analyze well with positive ionization, there are analytes that show better ionization efficiency with negative ionization, for example, acidic compounds. These analytes include ethanol metabolites such as ethyl glucuronide (ETG), ethyl sulfate (ETS), and the barbiturates such as amobarbital, butabarbital, butalbital, pentobarbital, phenobarbital, and secobarbital.
In this technical note, researchers demonstrated a method to simultaneously analyze ethanol metabolites and barbiturates in human urine using QTRAP®/Triple Quad 4500 LC-MS/MS system. Sample preparation is based on a simple “dilute and shoot” methodology. The method has a total runtime of 5 minutes, shows good sensitivity and is very robust. More than 800 continuous injections of human urine samples were performed on a single LC column with no deterioration in performance evident.
How does this test play out in real-world scenarios? ETG and ETS are biomarkers for determining the presence of alcohol over the past 80 hours where ETG is the direct metabolite of alcohol. ETG is only detected if alcohol has been consumed. What is more is that urine tests are the most common and inexpensive choice when testing for drug use and can be easily captured. Making sure results stand up in court, but also being able to run simultaneous drug screenings will help your lab keep up with sample workloads while also producing reliable results.
Customer Experience Day (CX Day) is a special occasion for SCIEX, celebrated every first Tuesday in October. It’s a day dedicated to recognizing the incredible value of our customers and the relentless dedication of our associates who strive to make every interaction meaningful. At SCIEX, our commitment to customer experience is woven into the fabric of everything we do. From providing cutting-edge solutions to offering unwavering support, we aim to build lasting relationships and exceed expectations. Join us as we delve into the insights from our leaders on what customer experience means to SCIEX and how it shapes our journey.
With the launch of the ZenoTOF 8600 system, EAD has taken a significant leap forward in becoming a routine tool for metabolomics and lipidomics workflows. Building on the foundation laid by the ZenoTOF 7600 system, the 8600 system introduces enhanced sensitivity, function speed improvements, and multimodal capabilities that make EAD more practical and scalable for daily use. This blog explores how these advancements are transforming EAD from a specialized technique into a robust and accessible solution for high-throughput structural analysis, enabling researchers to unlock deeper insights with greater efficiency.
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