GEN-MKT-18-7897-A
Jan 5, 2016 | Blogs, Forensic | 0 comments
What does every scientist think about in the lab? Validation. This is the feeling I encountered while reading a recent scientific report on nature.com. What struck me was not only the study itself which discounted cannabinoid incorporation into hair as a method for confirming consumption, but the test was carried out on the SCIEX QTRAP® 5500 linear ion-trap mass spectrometer. Here the authors produced a comprehensive LC-MS/MS study in which segmented hair samples (1 cm segments) were analyzed for THCA-A. Instead of using established GC/MS methods they were able to prove the validity of false positives as they applied to the presence of cannabinoids in hair samples.
Perhaps you have a study waiting to be published. Alternatively, maybe you are looking to push your lab into more extensive forensic testing this coming year. High-Resolution Accurate-Mass MS such as the X500R is proving to be the must-have instrument in every lab. However, how do you choose the right technology for your team? What is right for one lab is not the best option for another. Before you start spending, it is good to know some instruments come with way more technology than your lab might ever need while others are simply too routine. If you are in the market for mass spectrometry, here are some key points to remember:
The toolkit is loaded with research information including:
Forensic Toxicology Tests
The above article certainly brings into question the integrity of acquired results when challenged in the courtroom. If your lab is using old technology, we want to hear from you. Tell us what kind of experiments you are running and what are the setbacks you have encountered?
For research use only. Not for use in diagnostic procedures.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
CE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
At SCIEX, innovation doesn’t stop at instruments; it extends to how you interact with your LC-MS/MS or CE systems every day. That’s why we’re excited to introduce the SCIEX Now spring 2026 improvements: a set of meaningful enhancements shaped directly by your feedback.
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