GEN-MKT-18-7897-A
Oct 3, 2017 | Blogs, Technology | 0 comments
If you are a scientist working with complex assays, finding a way to significantly improve selectivity of detection could solve some of your biggest analytical headaches. Are we right? If so, then you are in the right place.
If you are confronted with assay selectivity challenges, then explore the SelexION® Differential Mobility Spectrometry (DMS) technology. SelexION technology delivers analyte separation that is orthogonal to mass separation, helping you to achieve a more selective MS assay, without returning to method development and complex sample preparation strategies.
If this is the first time you have read about the SelexION device, we suggest you also read the previous blog in this series where we introduced the ‘Science Behind SelexION DMS Technology’. Before you click on the link, keep reading to find out the top five ways that SelexION addresses your biggest analytical challenges.
Overcome these five common challenges and achieve a new dimension in selectivity by incorporating SelexION DMS separation on your SCIEX Triple Quad™, QTRAP®, or TripleTOF® System.
In monoclonal antibody (mAb) development, assessment of purity and integrity of the protein in question is critical. CE‑SDS is the gold standard assay and is routinely run from analytical development through QC and lot release. It’s trusted because it consistently delivers quantitative, size‑based insight into purity and fragmentation, and it fits naturally into regulated environments.
In drug discovery and development, Metabolite Identification (Met ID) plays a critical role in understanding biotransformation pathways, ensuring safety, and meeting regulatory requirements. Advanced mass spectrometry techniques have revolutionized this process, particularly through electron-based fragmentation methods such as Electron Activated Dissociation (EAD) and Electron Transfer Dissociation (ETD). While both techniques leverage electron interactions to generate informative fragment ions, they differ significantly in mechanism, performance, and suitability for Met ID workflows.
In analytical laboratories, performance is not optional. Whether supporting regulated pharmaceutical workflows, high-throughput CRO operations, clinical reporting, or food and environmental testing, your mass spectrometry and capillary electrophoresis systems are critical to productivity, compliance, and scientific confidence.
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