GEN-MKT-18-7897-A
Oct 3, 2017 | Blogs, Technology | 0 comments
If you are a scientist working with complex assays, finding a way to significantly improve selectivity of detection could solve some of your biggest analytical headaches. Are we right? If so, then you are in the right place.
If you are confronted with assay selectivity challenges, then explore the SelexION® Differential Mobility Spectrometry (DMS) technology. SelexION technology delivers analyte separation that is orthogonal to mass separation, helping you to achieve a more selective MS assay, without returning to method development and complex sample preparation strategies.
If this is the first time you have read about the SelexION device, we suggest you also read the previous blog in this series where we introduced the ‘Science Behind SelexION DMS Technology’. Before you click on the link, keep reading to find out the top five ways that SelexION addresses your biggest analytical challenges.
Overcome these five common challenges and achieve a new dimension in selectivity by incorporating SelexION DMS separation on your SCIEX Triple Quad™, QTRAP®, or TripleTOF® System.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
CE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
At SCIEX, innovation doesn’t stop at instruments; it extends to how you interact with your LC-MS/MS or CE systems every day. That’s why we’re excited to introduce the SCIEX Now spring 2026 improvements: a set of meaningful enhancements shaped directly by your feedback.
Posted by
You must be logged in to post a comment.
Share this post with your network