GEN-MKT-18-7897-A
Dec 4, 2017 | Blogs, Food / Beverage, Forensic | 0 comments
To date, when it comes to testing urine or oral fluids in the workplace not all psychoactive substances can be detected due to evolving substitutions. As legislation changes, so too do chemical formulations. Therefore researchers, like the authors of the following publication, A Validated Method for the Detection of 32 Bath Salts in Oral Fluids, published by Oxford Academic, analyze compounds using the best available methods so they can cast a wider net.
According to the National Institute on Drug Abuse, synthetic cathinones or bath salts, come from the khat plant in East Africa and Saudi Arabia. People use these drugs by accident or because they are less likely to be detected than drugs such as methamphetamine, MDMA, and cocaine. Which is why the more substances detected, the greater value your forensic lab can bring to workplace drug testing.Access the Publication >
While traditional analysis such as ELISA assays does exist to test for this widely used designer drug, there are limitations which the researchers in the tech note point out. Confirming a drug analysis, however, is critical to the integrity of your lab, and this research note offers a validated method using the SCIEX QTRAP® 6500 operated in electrospray positive mode and MultiQuant™ software. Even if you are not an expert, users can process and quantify large batches of data to get clear, reliable results in the least amount of time using the reporting tool.
Why Should Your Lab Use Mass Spec to Test for Cathinones or Bath Salts?
The Take-AwayMass Spectrometry is the solution to address NPS, from the artificial cannabinoids of the JWH family of compounds found in synthetic cannabis (K2/Spice), phenethylamines (with stimulant, entactogenic or hallucinogenic effects, such as PMMA and 2C-I), tryptamines (which have predominantly hallucinogenic effects, such as AMT and 5-MeO-DALT), piperazines (which exhibit predominantly stimulant effects, such as mCPP and BZP), or cathinones.
In monoclonal antibody (mAb) development, assessment of purity and integrity of the protein in question is critical. CE‑SDS is the gold standard assay and is routinely run from analytical development through QC and lot release. It’s trusted because it consistently delivers quantitative, size‑based insight into purity and fragmentation, and it fits naturally into regulated environments.
In drug discovery and development, Metabolite Identification (Met ID) plays a critical role in understanding biotransformation pathways, ensuring safety, and meeting regulatory requirements. Advanced mass spectrometry techniques have revolutionized this process, particularly through electron-based fragmentation methods such as Electron Activated Dissociation (EAD) and Electron Transfer Dissociation (ETD). While both techniques leverage electron interactions to generate informative fragment ions, they differ significantly in mechanism, performance, and suitability for Met ID workflows.
In analytical laboratories, performance is not optional. Whether supporting regulated pharmaceutical workflows, high-throughput CRO operations, clinical reporting, or food and environmental testing, your mass spectrometry and capillary electrophoresis systems are critical to productivity, compliance, and scientific confidence.
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