GEN-MKT-18-7897-A
Dec 4, 2017 | Blogs, Food / Beverage, Forensic | 0 comments
To date, when it comes to testing urine or oral fluids in the workplace not all psychoactive substances can be detected due to evolving substitutions. As legislation changes, so too do chemical formulations. Therefore researchers, like the authors of the following publication, A Validated Method for the Detection of 32 Bath Salts in Oral Fluids, published by Oxford Academic, analyze compounds using the best available methods so they can cast a wider net.
According to the National Institute on Drug Abuse, synthetic cathinones or bath salts, come from the khat plant in East Africa and Saudi Arabia. People use these drugs by accident or because they are less likely to be detected than drugs such as methamphetamine, MDMA, and cocaine. Which is why the more substances detected, the greater value your forensic lab can bring to workplace drug testing.Access the Publication >
While traditional analysis such as ELISA assays does exist to test for this widely used designer drug, there are limitations which the researchers in the tech note point out. Confirming a drug analysis, however, is critical to the integrity of your lab, and this research note offers a validated method using the SCIEX QTRAP® 6500 operated in electrospray positive mode and MultiQuant™ software. Even if you are not an expert, users can process and quantify large batches of data to get clear, reliable results in the least amount of time using the reporting tool.
Why Should Your Lab Use Mass Spec to Test for Cathinones or Bath Salts?
The Take-AwayMass Spectrometry is the solution to address NPS, from the artificial cannabinoids of the JWH family of compounds found in synthetic cannabis (K2/Spice), phenethylamines (with stimulant, entactogenic or hallucinogenic effects, such as PMMA and 2C-I), tryptamines (which have predominantly hallucinogenic effects, such as AMT and 5-MeO-DALT), piperazines (which exhibit predominantly stimulant effects, such as mCPP and BZP), or cathinones.
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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