GEN-MKT-18-7897-A
May 2, 2018 | Blogs, Forensic | 0 comments
Forensics depend on detection of even the smallest compounds to deliver results you can rely on. You need fast analysis methods that provide highly accurate data across a multitude of compounds and biomarkers, which enable you to uphold result integrity and get the truth from your samples.
Mass spectrometry has become fundamental to the evolution of forensic science. As instruments have become more sophisticated, law enforcement can now get results from the smallest samples of lingering traces of crime, in a manner that will stand up in court. However, the ever-increasing sensitivity and throughput requirements of forensic assays can pose method development challenges, even for the most powerful LC-MS/MS technology.
Getting the Right Answer is Crucial to Your Forensic InvestigationAs with many applications of quantitative analysis, forensic analytes can be difficult to accurately detect because of complex matrices or the presence of chemical interferences. Furthermore, compounds may be isobaric and consequentially challenging to separate with conventional separation technology.
Where LC-MS/MS sensitivity alone is not enough for complex assays that demand exceptionally selective quantitative and qualitative performance, Differential Ion Mobility Technology has proven to be a valuable addition.
SelexION® DMS Technology Will Breakthrough Sensitivity BarriersSelexION DMS Technology, coupled with QTRAP or TripleTOF LC-MS systems, can separate analytes of identical mass, reduce chemical noise, and improve quantitative accuracy, to rapidly deliver the forensic data you need. You can benefit from high throughput methods with little or no sample preparation and minimal chromatographic retention.
DMS separates ions based on the difference between their ion mobility’s in a high and low electric field in gases at or near atmospheric pressure. SelexION is placed in front of the inlet of the mass spectrometer, and the ionized molecules travel into the orthogonal geometry shaped DMS cell. Ions are separated on mobility scale due to differences in molecular size and shape, thereby providing highly selective analysis with minimal background interferences.
Advantages of the planar DMS geometry include:
SelexION offers a unique approach to separation that is unmatched by any other available method. Download the e-book to find out how we achieved LOD of 0.05 ng/mL and LOQ of 0.5 ng/mL using SelexION technology in the analysis of methyldienolone in urine, which were otherwise 2 and 5 ng/mL respectively without.
Find out about The Science Behind SelexION Differential Ion Mobility Technology and how SeleXION Addresses Your Biggest Analytical Challenges.
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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