GEN-MKT-18-7897-A
Oct 5, 2018 | Blogs, Forensic | 0 comments
Sadly, the world is a volatile place. The threat of organic explosive use by terrorists and criminals is very much with us, posing a significant danger to people worldwide. The rising concern for public safety is a top priority for national security organizations around the world, to be able to protect citizens, but also to act quickly in the event of an incident.
From fireworks to firearms, if an explosion occurs a detailed investigation reveals vital clues that help investigators piece together what happened. Whether in a war zone or civilian spaces, information from an exploded device will not only provide answers to support a case but will help us to assess better and understand the devastation that these objects can leave behind.
Advanced Analysis of Organic ExplosivesWith the daily occurrence of explosives found in crime scenes, advanced forensic analysis after blasts will help us to solve more crimes, stay ahead of more attacks and help neutralize threats. But it can be challenging to analyze trace amounts of organic explosive residue. Traditional analytical methods often fail to provide the essential throughput and selectivity required to identify key components of a crime scene involving explosives.
Forensic scientists need sensitive and accurate screening techniques to identify explosive materials, fast.High-resolution liquid chromatography-mass spectrometry (HPLC-MS) provides the answer. With acquisition rates at up to 100 MS/MS per second and the ability to perform comprehensive analysis, samples left behind from organic explosives can be analyzed in under three minutes. This, of course, includes the 14 most important known explosives making it hard to find another analytical method that comes close. HPLC-MS offers a greater level of explosive occurrence information leading to increased confidence in compound identifications.
We can bring this to life for you in this technical note: High Throughput Platform for Confident Identification and Quantitation of Organic Explosives. You will see how the SCIEX X500R System powered by SCIEX OS Software delivers fast, specific and sensitive analysis of the most common organic explosives encountered in forensic analytical settings, and how we achieve the levels of performance detailed above.
Complete the form on the right to download the Forensics Compendium that features this tech note.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
CE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
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