GEN-MKT-18-7897-A
Feb 5, 2019 | Blogs, Forensic | 0 comments
Do you want a more efficient workflow for the forensic analysis of THC-COOH in hair samples? Yes! Do we know a simple, highly sensitive technique? You bet! Read on to find out how you can detect THC-COOH in hair down to 0.2 pg/mg trace concentration levels with excellent accuracy (>95%) and precision (<15%).
Marijuana is the most widely used recreational drug in the world, with reported users as high as 234.1 million worldwide. Forensic toxicology labs face the task of testing hundreds of thousands of samples every year to identify drug misuse in relation to a range of civil and criminal investigations, such as intoxicated driving investigations, child custody cases, sexual assault cases, and parole abstinence monitoring.
The presence of the main marijuana metabolite – THC-COOH – can be detected in urine, blood, and saliva and indicate active drug use. While these biological fluids are valuable in determining use in the short term, hair testing offers an advantage due to its larger detection window. Consequently, for accurate detection of long-term cannabis use (up to 90 days), hair samples are far more reliable sources and are widely accepted in criminal and civil courts.
However, using hair for detecting cannabis does provide its own analytical challenges. Firstly, the concentration of THC-COOH in hair samples is characteristically low, and secondly, there is a high abundance of matrix interferences that specifically impact the detection of THC-COOH.
Efficient Workflow. Sensitive Detection. Accurate Results.As you probably know, our team love an analytical challenge; things around here wouldn’t be the same without them! And so, we have pleasure in presenting an efficiently designed analysis approach that gives accurate results. Our workflow combines the TripleQuad™ 4500 LC-MS/MS System with a solid phase extraction procedure that allows the reliable and sensitive detection of THC-COOH at trace levels (0.2 pg/mg) in hair matrix.
Find the complete technote, ‘Efficiently Designed Workflows Provide Accurate Results in Forensic Analysis of THC-COOH in Hair Samples’ in our Forensics Compendium, fill out the form on your right to download it today.
Without giving too much away in this blog, we wanted to share the top three highlights:
This workflow for the forensic analysis of THC-COOH in hair samples is ready to be integrated into your forensic toxicology laboratory. You will experience more accurate results with a more efficient workflow designed to support optimum throughput and sensitivity.
To find out more download the full technote, by filling out the form on your right, today.
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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