GEN-MKT-18-7897-A
Feb 27, 2019 | Blogs, Food / Beverage | 0 comments
A few months back, the American Academy of Pediatrics published a technical report on the use of chemicals in food processing and the negative health effects on children. One of the main culprits is phthalates.
The 411 of PhthalatesPhthalates are esters of phthalic acid ― refers to 3 isomers: ortho-isomer or phthalic acid, tere phthalic acid, and meta-isomer iso-phthalic acid. These group of chemical compounds are primarily used to make polyvinyl chloride (PVC) or vinyl flexible and pliant to increases flexibility, transparency, and longevity of these products. By weight, they contribute 10-60% of plastic products in our homes, hospitals, cars, and businesses ― detergents, toys, and even in some soaps and shampoos. Talk about an “Everywhere Chemical”!
Phthalates do not chemically bind to the material they are added to, they break down and escape. In other words, water solubility is low and may not biodegrade in the environment. This is particularly concerning when some phthalates have been linked to endocrine disruption, cancer, reproduction and development issues.1,2 The Centers for Disease Control and Prevention (CDC) found that phthalate exposure is widespread in the U.S. population with measurable levels in the general population.
Depending on molecular weight, phthalates are categorized as:
Phthalates in the Food Chain?That’s right. Unfortunately, studies have found phthalates can migrate into food preparation and packaging. From gloves used in food prep, tubing typically used in milk processing, food-packing films, and even coating from cookware.3,4,5,6
In some cases, the use of these chemicals can be illegal. For instance, in 2011 it reported in Taiwan that bis(2-ethylhexyl) phthalate (DEHP) and Diisononyl phthalate (DINP) were illegally used in clouding agents for use in food and beverages.7
Pretty scary, huh? As if the toxicity of these chemicals isn’t bad enough, the nature of these chemicals complicates detection and quantitation. A food testing lab will need to determine a range of phthalate metabolites in different food matrices with varying acceptable chemical limits. Coupled with chemical background and matrix interferences, it’s difficult to accurately sift through it all and accurately identify these compounds.
Detect Phthalates and Other Food Migrants in Food and Beverage Packages Quickly with LC-MS/MSBeyond shelf appeal, food wrappers, packaging, and preparation utensils like gloves protect food from micro-organisms, biological and chemical contaminants. However, a lesser-known fact, that same material could migrate into the actual food we are trying to protect.
Fret not; our team has developed a technical note to demonstrate the:
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References
In monoclonal antibody (mAb) development, assessment of purity and integrity of the protein in question is critical. CE‑SDS is the gold standard assay and is routinely run from analytical development through QC and lot release. It’s trusted because it consistently delivers quantitative, size‑based insight into purity and fragmentation, and it fits naturally into regulated environments.
In drug discovery and development, Metabolite Identification (Met ID) plays a critical role in understanding biotransformation pathways, ensuring safety, and meeting regulatory requirements. Advanced mass spectrometry techniques have revolutionized this process, particularly through electron-based fragmentation methods such as Electron Activated Dissociation (EAD) and Electron Transfer Dissociation (ETD). While both techniques leverage electron interactions to generate informative fragment ions, they differ significantly in mechanism, performance, and suitability for Met ID workflows.
In analytical laboratories, performance is not optional. Whether supporting regulated pharmaceutical workflows, high-throughput CRO operations, clinical reporting, or food and environmental testing, your mass spectrometry and capillary electrophoresis systems are critical to productivity, compliance, and scientific confidence.
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