GEN-MKT-18-7897-A
Feb 27, 2019 | Blogs, Food / Beverage | 0 comments
A few months back, the American Academy of Pediatrics published a technical report on the use of chemicals in food processing and the negative health effects on children. One of the main culprits is phthalates.
The 411 of PhthalatesPhthalates are esters of phthalic acid ― refers to 3 isomers: ortho-isomer or phthalic acid, tere phthalic acid, and meta-isomer iso-phthalic acid. These group of chemical compounds are primarily used to make polyvinyl chloride (PVC) or vinyl flexible and pliant to increases flexibility, transparency, and longevity of these products. By weight, they contribute 10-60% of plastic products in our homes, hospitals, cars, and businesses ― detergents, toys, and even in some soaps and shampoos. Talk about an “Everywhere Chemical”!
Phthalates do not chemically bind to the material they are added to, they break down and escape. In other words, water solubility is low and may not biodegrade in the environment. This is particularly concerning when some phthalates have been linked to endocrine disruption, cancer, reproduction and development issues.1,2 The Centers for Disease Control and Prevention (CDC) found that phthalate exposure is widespread in the U.S. population with measurable levels in the general population.
Depending on molecular weight, phthalates are categorized as:
Phthalates in the Food Chain?That’s right. Unfortunately, studies have found phthalates can migrate into food preparation and packaging. From gloves used in food prep, tubing typically used in milk processing, food-packing films, and even coating from cookware.3,4,5,6
In some cases, the use of these chemicals can be illegal. For instance, in 2011 it reported in Taiwan that bis(2-ethylhexyl) phthalate (DEHP) and Diisononyl phthalate (DINP) were illegally used in clouding agents for use in food and beverages.7
Pretty scary, huh? As if the toxicity of these chemicals isn’t bad enough, the nature of these chemicals complicates detection and quantitation. A food testing lab will need to determine a range of phthalate metabolites in different food matrices with varying acceptable chemical limits. Coupled with chemical background and matrix interferences, it’s difficult to accurately sift through it all and accurately identify these compounds.
Detect Phthalates and Other Food Migrants in Food and Beverage Packages Quickly with LC-MS/MSBeyond shelf appeal, food wrappers, packaging, and preparation utensils like gloves protect food from micro-organisms, biological and chemical contaminants. However, a lesser-known fact, that same material could migrate into the actual food we are trying to protect.
Fret not; our team has developed a technical note to demonstrate the:
For further information, download this free method today by completing the form on the right.
References
Produced by certain moulds, thriving in crops such as grain, nuts and coffee, mycotoxins have contaminated agriculture and food production industries for a long time. To intensify the challenge, mycotoxins are resilient, not easily broken down and ensuring the safety of food supply chains requires comprehensive solutions and we are here to share those solutions with you.
Electron-Activated Dissociation (EAD) is transforming the fields of metabolomics and lipidomics by providing enhanced fragmentation techniques that offer deeper insights into molecular structures. In September, Technology Networks hosted a webinar, “Enhancing Mass-Based Omics Analysis in Model Organisms,” featuring Dr. Valentina Calabrese from the Institute of Analytical Sciences at the University of Lyon. Valentina shared her insights on improving omics-based mass spectrometry analysis for toxicology studies using model organisms, particularly in metabolomics and lipidomics. This blog explores the additional functionalities EAD offers, its benefits in untargeted workflows, its incorporation into GNPS and molecular networking, and the future role it could play in these scientific domains.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has gained significant attention in the clinical laboratory due to its ability to provide best-in-class sensitivity and specificity for the detection of clinically relevant analytes across a wide range of assays. For clinical laboratories new to LC-MS/MS, integrating this technology into their daily routine operations may seem like a daunting task. Developing a clear outline and defining the requirements needed to implement LC-MS/MS into your daily operations is critical to maximize the productivity and success of your clinical laboratory.
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