GEN-MKT-18-7897-A
Jun 27, 2019 | Blogs, Technology | 0 comments
Choosing the best technique for your analysis can be tough. Should you go with gas chromatography/mass spectrometry (GC-MS) or liquid chromatography/tandem mass spectrometry (LC-MS/MS)? That’s the key question. That’s why we’re here to help.
The Limitations of GC-MSGC-MS is an established technique to analyze volatile organic compounds (VOCs) and trihalomethanes (THMs). Simply put, it’s a technique that’s best used for thermally stable molecules. Traditionally, GC-MS is the preferred technique for the analysis of less polar and more volatile compounds such as organochlorine pesticides, dioxins, and polychlorinated biphenyl.
While the technique can offer good separation, the high temperatures used for vaporization during GC analysis can alter or degrade half of the analytes in a sample1. This is the primary concern for life science researchers who deal with relatively labile biological molecules that break down easily at high temperatures. GC-MS also becomes a challenge because it can involve labor-intensive sample preparation and long chromatographic run times.
The LC-MS/MS AdvantageLC-MS/MS combines the separation power of liquid chromatography with the identification and quantification power of tandem mass spectrometry.
The strength of this technique is in the ability of LC to separate a wide range of compounds before the tandem MS quantifies them with a high degree of sensitivity and selectivity based on the unique mass/charge (m/z) transitions of each compound of interest.
LC-MS/MS systems offer these basic benefits:
Many scientists who need increased levels of sensitivity, reproducibility, and robustness over GC-MS are either considering or have already made the leap to LC-MS/MS. When will you?
Let SCIEX Help You Make the Leap from GC-MS to LC-MS/MS
If your budget is holding you back, we have news for you. The SCIEX Triple Quad™ 3500 System provides all the advantages of modern LC-MS/MS technology. It’s the ideal choice for labs operating on a tight budget, and its simplicity of operation has the potential to expand your operation beyond the restrictions of gas chromatography.
Simply put, the Triple Quad 3500 LC-MS/MS System explained in fewer than 140 characters: Legendary power, speed, and accuracy are more affordable than ever.
Download your copy of the compendium to see what the SCIEX Triple Quad 3500 LC-MS/MS system can do for your laboratory.
Reference:
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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