GEN-MKT-18-7897-A
Jun 27, 2019 | Blogs, Technology | 0 comments
Choosing the best technique for your analysis can be tough. Should you go with gas chromatography/mass spectrometry (GC-MS) or liquid chromatography/tandem mass spectrometry (LC-MS/MS)? That’s the key question. That’s why we’re here to help.
The Limitations of GC-MSGC-MS is an established technique to analyze volatile organic compounds (VOCs) and trihalomethanes (THMs). Simply put, it’s a technique that’s best used for thermally stable molecules. Traditionally, GC-MS is the preferred technique for the analysis of less polar and more volatile compounds such as organochlorine pesticides, dioxins, and polychlorinated biphenyl.
While the technique can offer good separation, the high temperatures used for vaporization during GC analysis can alter or degrade half of the analytes in a sample1. This is the primary concern for life science researchers who deal with relatively labile biological molecules that break down easily at high temperatures. GC-MS also becomes a challenge because it can involve labor-intensive sample preparation and long chromatographic run times.
The LC-MS/MS AdvantageLC-MS/MS combines the separation power of liquid chromatography with the identification and quantification power of tandem mass spectrometry.
The strength of this technique is in the ability of LC to separate a wide range of compounds before the tandem MS quantifies them with a high degree of sensitivity and selectivity based on the unique mass/charge (m/z) transitions of each compound of interest.
LC-MS/MS systems offer these basic benefits:
Many scientists who need increased levels of sensitivity, reproducibility, and robustness over GC-MS are either considering or have already made the leap to LC-MS/MS. When will you?
Let SCIEX Help You Make the Leap from GC-MS to LC-MS/MS
If your budget is holding you back, we have news for you. The SCIEX Triple Quad™ 3500 System provides all the advantages of modern LC-MS/MS technology. It’s the ideal choice for labs operating on a tight budget, and its simplicity of operation has the potential to expand your operation beyond the restrictions of gas chromatography.
Simply put, the Triple Quad 3500 LC-MS/MS System explained in fewer than 140 characters: Legendary power, speed, and accuracy are more affordable than ever.
Download your copy of the compendium to see what the SCIEX Triple Quad 3500 LC-MS/MS system can do for your laboratory.
Reference:
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has gained significant attention in the clinical laboratory due to its ability to provide best-in-class sensitivity and specificity for the detection of clinically relevant analytes across a wide range of assays. For clinical laboratories new to LC-MS/MS, integrating this technology into their daily routine operations may seem like a daunting task. Developing a clear outline and defining the requirements needed to implement LC-MS/MS into your daily operations is critical to maximize the productivity and success of your clinical laboratory.
In today’s rapidly evolving food industry, the role of food testing laboratories has never been more critical. Ensuring the safety, quality, and authenticity of food products is paramount, and this responsibility falls heavily on the shoulders of laboratory managers. The economics of food testing—encompassing everything from high-throughput pesticide screening to advanced research on alternative protein sources—plays a pivotal role in shaping the operational efficiency and financial health of these laboratories.
Imagine having a tech expert at your fingertips to solve computer issues or a fitness trainer guiding you through workouts from the comfort of your home. In today’s fast-paced world, the ability to provide and receive service and support remotely is no longer a luxury but a necessity. Whether it’s troubleshooting a software issue, repairing a device, offering customer assistance, or enjoying the convenience of telehealth as a private individual, remote capabilities have revolutionized how businesses operate and how individuals get help
Posted by
You must be logged in to post a comment.
Share this post with your network