GEN-MKT-18-7897-A
Dec 19, 2019 | Blogs, Pharma | 0 comments
Over the last several years there has been a slow and steady progression within the LC-MS community to move traditional high-flow applications to lower flow rates. In particular, moving into the microflow regime has proven to be a simple adjustment in methodology that can result in a lot of gain for only a little pain. Microflow chromatography can provide an instant boost in sensitivity because of the increased ionization efficiency at lower flow rates. Additionally, microflow chromatography can lower solvent consumption and reagent costs and reduce downtime spent on routine instrument cleaning.
In the recent webinar Microflow Chromatography: The Key to More Sensitive Met ID, we discuss the benefits of microflow chromatography for metabolite ID applications. We compare microflow versus high flow for the identification of metabolites from several well-characterized drugs. The results are clear. Microflow provides:
As a follow-up to the webinar, we wanted to take the opportunity to answer some questions we received about using microflow for metabolite ID. After watching the presentation and reading our answers, we hope you will be convinced to consider microflow chromatography for your metabolite ID applications, too.
In a recent webinar, available on demand, scientists Luiza Chrojan and Ryan Hylands from Pharmaron, provided insights into the deployment of capillary gel electrophoresis (CGE) within cell and gene therapy. Luiza and Ryan shared purity data on plasmids used for adeno-associated virus (AAV) manufacturing and data on AAV genome integrity, viral protein (VP) purity and VP ratios using the BioPhase 8800 system.
Last year, Technology Networks hosted two webinars that featured groundbreaking research utilizing SWATH DIA (data-independent acquisition) for exposomics and metabolomics. Researchers Dr. Vinicius Verri Hernandes from the University of Vienna and Dr. Cristina Balcells from Imperial College London (ICL) demonstrated how a DIA approach can be successfully implemented in small molecule analysis using the ZenoTOF 7600 system. Their innovative approaches highlight the potential of SWATH DIA to enhance the detection and analysis of chemical exposures and metabolites, paving the way for new insights into environmental health and disease mechanisms.
For as long as PFAS persist in the environment, there is no doubt they will persist in our conversations as environmental scientists. Globally, PFAS contamination has been detected in water supplies, soil and even in the blood of people and wildlife. Different countries are at various stages of addressing PFAS contamination and many governments have set regulatory limits and are working on assessing the extent of contamination, cleaning up affected sites and researching safer alternatives.
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