Christie Hunter


Journal publications using the Echo® MS system

The Echo® MS system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small molecules, metabolites, and peptides. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and the SCIEX Triple Quad 6500+ mass spectrometer, learn more about the platform here.

Learn more about the technology and the applications enabled from these select journal publications.


Echo® MS system technology

  • Shou WZ. (2022) Acoustic ejection mass spectrometry: Development, applications, and future perspective. Biomed Chromatogr. 36(2):e5278.
  • Zhang H, Liu C, Hua W, Ghislain LP, Liu J, Aschenbrenner L, Noell S, Dirico KJ, Lanyon LF, Steppan CM, West M, Arnold DW, Covey TR, Datwani SS, Troutman MD. (2021) Acoustic Ejection Mass Spectrometry for High-Throughput Analysis. Analytical Chemistry. 93(31):10850-10861.
  • Liu C, Van Berkel GJ, Cox DM, Covey TR. (2020) Operational Modes and Speed Considerations of an Acoustic Droplet Dispenser for Mass Spectrometry. Analytical Chemistry. 92(24):15818-15826. 
  • Häbe TT, Liu C, Covey TR, Simon RP, Reindl W, Büttner FH, Winter M, Bischoff D, Luippold AH, Runge F. (2020) Ultrahigh-Throughput ESI-MS: Sampling Pushed to Six Samples per Second by Acoustic Ejection Mass Spectrometry. Analytical Chemistry. 92(18):12242-12249.
  • Liu C, Van Berkel GJ, Kovarik P, Perot JB, Inguva V, Covey TR. (2021) Fluid Dynamics of the Open Port Interface for High-Speed Nanoliter Volume Sampling Mass Spectrometry. Analytical Chemistry. 93(24):8559-8567.


High-throughput screening

  • DiRico KJ, Hua W, Liu C, Tucker JW, Ratnayake AS, Flanagan ME, Troutman MD, Noe MC, Zhang H. (2020) Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry. ACS Medicinal Chemistry Letters. 11(6):1101-1110.
  • Zhang J, Zhang Y, Liu C, Covey T, Nielsen J, Li S, Weller H, Shou W. (2021) Acoustic Ejection/Full-Scan Mass Spectrometry Analysis for High-Throughput Compound Quality Control. SLAS Technology. 26(2):178-188.
  • Wen X, Liu C, Ghislain L, Tovar K, Shah V, Stout SJ, Cifelli S, Satapati S, O’Donnell G, Sheth PR, Wildey MJ, Datwani SS, Covey TR, Bateman KP, McLaren DG. (2021) Direct Analysis from Phase-Separated Liquid Samples using ADE-OPI-MS: Applicability to High-Throughput Screening for Inhibitors of Diacylglycerol Acyltransferase 2. Analytical Chemistry. 93(15):6071-6079.
  • Hasegawa T, Imamura RM, Suzuki T, Hashiguchi T, Nomura T, Otsuguro S, Maenaka K, Sasaki M, Orba Y, Sawa H, Sato A, Okabe T, Nagano T, Kojima H. (2021) Application of Acoustic Ejection MS System to High-Throughput Screening for SARS-CoV-2 3CL Protease Inhibitors. Chemical and pharmaceutical bulletin (Tokyo).
  • Simon RP, Häbe TT, Ries R, Winter M, Wang Y, Fernández-Montalván A, Bischoff D, Runge F, Reindl W, Luippold AH, Büttner FH. (2021) Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery. SLAS Discovery. 26(8):961-973.


High-throughput ADME


Platform and extraction optimization

  • Guo Y, Forbush M, Covey TR, Ghislain L, Liu C. (2021) High-Throughput Analysis from Complex Matrices: Acoustic Ejection Mass Spectrometry from Phase-Separated Fluid Samples. Metabolites. 11(11):789.



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