GEN-MKT-18-7897-A
Dec 23, 2025 | Blogs, Pharma, QTRAP / Triple Quad | 0 comments
Read time: 3 minutes
Investing in a new liquid chromatography-mass spectrometry (LC-MS) system is a big decision, especially when your lab handles a wide variety of analytical tasks. With so many options out there, it’s easy to feel overwhelmed.
That’s where this blog comes in. We’ll walk you through the bioanalytical quantitation solutions offered by SCIEX, helping you better understand which system might be the best fit for your current needs and future ambitions.
SCIEX doesn’t offer a one-size-fits-all approach. There are several LC-MS systems, each with its own strengths. So, whether you’re focused on today’s workflows or planning for tomorrow’s challenges, there’s a solution that aligns with your goals.
Let’s dig into this in more detail because life is never this simple.
Routine bioanalysis
When it comes to bioanalysis, SCIEX has been a trusted name in quadrupole mass spectrometry for as long as most of us can remember. But it’s not just about the hardware. We’re proud of the reliability, support, and innovation that come with every LC-MS system we offer.
All our instruments run on SCIEX OS software, a powerful yet intuitive platform designed to simplify your workflow. Whether you’re working in a regulated environment or not, using compliance-ready software from the start can be a smart move. It helps streamline method development and makes future transitions into regulated bioanalytical spaces smoother and faster.
Here is an example of the performance you can expect from the system, Highly sensitive LC-MS/MS method for the quantification of fluticasone propionate in human plasma using the SCIEX QTRAP 6500 System
Routine bioanalysis requiring higher sensitivity
As technology has developed, mass spectrometers have become more sensitive and what was considered a nice-to-have feature is now often essential. If you need to see trace-level analytes or your matrices are very complex, the 7500+ system is the better option for you.
Curious to see examples of what the 7500+ system can do?
Sensitive quantitation of glucagon-like peptide-1 (GLP-1) analog in rat plasma
Comprehensive LC-MS workflows for antibody drug conjugate (ADC) analysis
Flexible Quant/Qual system, more selectivity, or larger analytes
In the last 5 years, improvements in the quantitative performance and sensitivity of time-of-flight (TOF) technology has made it more attractive to bioanalysis labs. The ability to offer both quantitation and qualitative information on a single system makes life easier. Also, as drug modalities have changed and test compounds have become larger, they have exceeded the mass range of quadrupole systems making a TOF essential.
Additional benefits of a TOF are increased selectivity allowing low-level analytes to be distinguished from complex matrices. This can allow for shorter run times and reduced sample preparation.
Discover more about how the ZenoTOF 7600 could help in your lab, here:
Sensitive quantification of insulin lispro using accurate mass spectrometry (sciex.com)
High resolution LC-MS/MS solution for improved quantitation of peptides in a complex matrix
For more information on the options SCIEX has for bioanalysis please speak to your account manager or this technology pack may be of interest to you, New Frontiers in Bioanalysis.
Why not join the Mass spec bioanalysis community on LinkedIn?
The community offers the opportunity to:
Follow the link to join, here
In monoclonal antibody (mAb) development, assessment of purity and integrity of the protein in question is critical. CE‑SDS is the gold standard assay and is routinely run from analytical development through QC and lot release. It’s trusted because it consistently delivers quantitative, size‑based insight into purity and fragmentation, and it fits naturally into regulated environments.
In drug discovery and development, Metabolite Identification (Met ID) plays a critical role in understanding biotransformation pathways, ensuring safety, and meeting regulatory requirements. Advanced mass spectrometry techniques have revolutionized this process, particularly through electron-based fragmentation methods such as Electron Activated Dissociation (EAD) and Electron Transfer Dissociation (ETD). While both techniques leverage electron interactions to generate informative fragment ions, they differ significantly in mechanism, performance, and suitability for Met ID workflows.
In analytical laboratories, performance is not optional. Whether supporting regulated pharmaceutical workflows, high-throughput CRO operations, clinical reporting, or food and environmental testing, your mass spectrometry and capillary electrophoresis systems are critical to productivity, compliance, and scientific confidence.
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