GEN-MKT-18-7897-A
Oct 11, 2017 | Blogs, Technology | 0 comments
If you are working with complex assays that demand exceptionally selective quantitative and qualitative performance, sometimes even the most powerful LC-MS/MS technology can’t always cut it alone.
Perhaps you are struggling to separate isobaric species, isolate challenging co-eluting analytes or reduce high background noise? Regardless of your challenge, the outcome is the same. You probably aren’t getting the levels of quantitation or characterization you need, so method development has become cumbersome, and workflow performance is suffering.
Now you can bring a new dimension of selectivity to your LC-MS/MS analysis on select SCIEX Triple Quad™, QTRAP® and TripleTOF® Systems with SelexION® Differential Mobility Separation (DMS) Technology. The SelexION DMS cell:
Harness the power of differential mobility separations to simplify your sample preparations, while achieving unprecedented levels of selectivity. Find out more by downloading the SelexION brochure.
How does it work?Gas phase differential mobility separation within the SelexION device planar mobility cell is based on the ion’s size and shape, and the difference between their unique differential mobilities across high and low energy fields. Gas phase separation occurs prior to entering the mass analyzer where the compounds are then further separated by m/z ratios.
In drug discovery and development, Metabolite Identification (Met ID) plays a critical role in understanding biotransformation pathways, ensuring safety, and meeting regulatory requirements. Advanced mass spectrometry techniques have revolutionized this process, particularly through electron-based fragmentation methods such as Electron Activated Dissociation (EAD) and Electron Transfer Dissociation (ETD). While both techniques leverage electron interactions to generate informative fragment ions, they differ significantly in mechanism, performance, and suitability for Met ID workflows.
In analytical laboratories, performance is not optional. Whether supporting regulated pharmaceutical workflows, high-throughput CRO operations, clinical reporting, or food and environmental testing, your mass spectrometry and capillary electrophoresis systems are critical to productivity, compliance, and scientific confidence.
Naturally occurring toxins are an unavoidable reality of today’s global food supply, and among them, alkaloids represent one of the most analytically challenging and safety‑critical compound classes. Produced by plants as natural defence mechanisms, alkaloids can unintentionally enter food through contamination, co‑harvesting, or adulteration, posing serious risks to consumer health and regulatory compliance.
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