GEN-MKT-18-7897-A
Dec 6, 2016 | Blogs, Food / Beverage | 0 comments
Are you looking for ways to up the ante on your LC-MS/MS when it comes to food testing? Researchers here have developed a method for the analysis of approximately 400 pesticides in food samples, and their work is available for viewing in this year’s compendium. This application note is just one of 16 you will find under Pesticides >
Using your QTRAP® LC-MS/MS System at its Full Potential OverviewUsing MRM mode, the QTRAP® 6500 LC-MS/MS was used to quantify hundreds of pesticides in food samples with high selectivity and sensitivity. Identification was further confirmed using MRM ratio identification. An alternative approach for compound identification went beyond the detection of multiple fragments.
Details of ExperimentTwenty pesticides were spiked into different food samples, and diluted extracts were analyzed using two methods.
Results and ConclusionsImproved data processing using a dual injection approach with automatic quantitation, identification, and confirmation using MasterView™ and MultiQuant™ Software. Results highlight the complementary nature of MRM ratios and MS/MS full scan offering a possibility of confirmatory analysis.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
CE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
At SCIEX, innovation doesn’t stop at instruments; it extends to how you interact with your LC-MS/MS or CE systems every day. That’s why we’re excited to introduce the SCIEX Now spring 2026 improvements: a set of meaningful enhancements shaped directly by your feedback.
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