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It’s Time to Enhance Your Food Testing

Dec 6, 2016 | Blogs, Food / Beverage | 0 comments

Are you looking for ways to up the ante on your LC-MS/MS when it comes to food testing? Researchers here have developed a method for the analysis of approximately 400 pesticides in food samples, and their work is available for viewing in this year’s compendium. This application note is just one of 16 you will find under Pesticides >

Using your QTRAP® LC-MS/MS System at its Full Potential Overview
Using MRM mode, the QTRAP® 6500 LC-MS/MS was used to quantify hundreds of pesticides in food samples with high selectivity and sensitivity. Identification was further confirmed using MRM ratio identification. An alternative approach for compound identification went beyond the detection of multiple fragments.

Details of Experiment
Twenty pesticides were spiked into different food samples, and diluted extracts were analyzed using two methods.

Results and Conclusions
Improved data processing using a dual injection approach with automatic quantitation, identification, and confirmation using MasterView™ and MultiQuant™ Software. Results highlight the complementary nature of MRM ratios and MS/MS full scan offering a possibility of confirmatory analysis. 

Addressing stability challenges of mRNA-LNP therapies

In a recent webinar, available on demand, Jingtao Zhang (PhD), Scientific Director, and Daniel Turner, Scientist at Catalent® Pharma Solutions, presented their approaches to addressing stability challenges of mRNA-based products.

Questions and answers to help improve your mycotoxin analysis

During a recent webinar I shared method details for mycotoxin analysis on the SCIEX 7500 system. In this blog i will share the Q&A for the submitted questions that we did not have chance to answer during the live webinar.

A 2-fold revolution: MS approaches for the bioanalysis of oligonucleotide therapeutics

In 1998, the US Food and Drug Administration (FDA) approved fomivirsen as the first therapeutic oligonucleotide therapeutic. This approval marked a revolution of mechanism of action discovered decades before finally coming to fruition. Since then, the landscape of chemical modifications of oligonucleotides, conjugations and formulations has evolved tremendously, contributing to improvements in stability, efficacy and safety. Today, more than a dozen antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) drugs are on the market, most of which are designated as orphan drugs for treating rare genetic diseases.

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