GEN-MKT-18-7897-A
Jun 22, 2018 | Blogs, Environmental / Industrial, Food / Beverage | 0 comments
How do you safeguard human health and protect your reputation through meeting stringent global food and environmental safety standards?
When it comes to testing food and environmental samples, the quality of your testing data is vital to your business. You need fast and accurate analytical techniques that help enable you to reliably identify and quantify hundreds of chemical contaminants and residues in a single run.
Liquid chromatographic techniques coupled with mass spectrometry (LC-MS) has become the method of choice, offering excellent levels of sensitivity and selectivity. It provides a robust and flexible solution, with high-quality data, which helps you meet maximum residue limits and achieve the lowest possible detection limits, at trace levels with the ultimate accuracy.
When You Need to Push the Limits Even FurtherWhen testing for food and environmental contaminants, you often face analytical challenges that demand a more advanced level of selectivity. Some compounds can be troublesome to reproducibly detect due to complex matrices. These compounds may also be isomeric and so problematic to separate using conventional approaches. This is where your mass spec workflows could benefit from an additional level of separation.
SelexION® DMS Technology from SCIEX can deliver an orthogonal level of separation for your most challenging samples. Instead of returning to method development, it allows you to reduce background noise and eliminate interference from your sample, so you can separate highly similar compounds.
The Reliable Results and Fast Turnaround Times Your Lab NeedsSelexION is a small, planar mobility cell that can significantly help you increase analytical separation power. Coupled with a SCIEX LC-MS/MS system, it enables robust and reproducible detection of food or environmental contaminants.
Do you want to know more? We thought you might, so we have developed some tech notes to support you in your quest to achieve highly selective and sensitive analyses in food and environmental testing:
When it comes to meeting regulatory demands and keeping our food and environment safe from pesticides and other contaminants, look no further than SelexION DMS Technology. Download the eBook and get access to these technical papers, and so much more. Find out about The Science Behind SelexION.
Differential Ion Mobility Technology and how SelexION Addresses Your Biggest Analytical Challenges.
References1.https://www.foodnavigator.com/Article/2017/12/14/LC-MS-MS-method-of-choice-for-multi-residue-analysis-and-quantitation
As an analytical strategy, middle-down mass spectrometry (MS) workflows characterize biotherapeutic proteins by analyzing large, digested protein fragments or defined subunits, rather than fully intact proteins (top-down) or digested peptides (bottom-up). A middle-down strategy combines the strengths of top-down and bottom-up approaches by delivering high sequence coverage and structural specificity while maintaining relatively simple sample preparation. In practice, middle-down analysis enables accurate mass measurement, rapid sequence confirmation, and localization of key post-translational modifications (PTMs) on protein subunits that are directly relevant to product quality.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
CE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
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