Harness the power of LC-MS/MS in your clinical laboratory by Pierre Negri | Apr 17, 2025 | Blogs, ClinicalRead time: 4 minutes Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has gained significant attention in the clinical laboratory due to its ability to provide best-in-class sensitivity and specificity for the detection of clinically relevant analytes across...
FDA’s final rule on LDTs: what does it mean for clinical laboratories? by Pierre Negri | Sep 17, 2024 | Blogs, ClinicalRead time: 5 minutes On April 29, 2024, the U.S. Food and Drug Administration (FDA) announced a final rule regulating laboratory developed tests (LDTs) as in vitro diagnostic devices (IVDs) under the Federal Food, Drug and Cosmetic Act (FD&C Act). This rule amends...
Maximize NPS analysis with accurate mass spectrometry by Pierre Negri | Mar 11, 2024 | Blogs, Forensic, SCIEX OS software, Toxicology, ZenoTOF 7600 systemRead time: 4 minutes LC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many...
Unlock the benefits of nominal mass spectrometry for NPS analysis by Pierre Negri | Mar 11, 2024 | Blogs, Clinical, Forensic, QTRAP / Triple Quad, ToxicologyThe development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and...
Analytical techniques for novel psychoactive substances (NPS) screening by Pierre Negri | Apr 21, 2023 | Blogs, Forensic, ToxicologyRead time: 10 minutes The increased prevalence of novel psychoactive substances (NPS) in the recreational drug market has been a major contributor to the ongoing opioid crisis. NPS are newly emerging compounds designed to mimic existing recreational drugs and have...
The age of novel psychoactive substances by Pierre Negri | Mar 9, 2023 | Blogs, Forensic, ToxicologyRead time: 10 min Novel psychoactive substances (NPS) are compounds designed to mimic existing recreational drugs. The emergence of NPS has changed the landscape of the synthetic drug market. While previously the market had a limited number of compounds belonging to a...
Having issues differentiating CBD from THC in hemp-derived products? by Pierre Negri | Aug 8, 2021 | Cannabis, Forensic, QTRAP / Triple Quad, Results, SCIEX information, ToxicologyThe popularity of CBD products has been on the rise following a federal move to legalize hemp. In an effort to regulate the sale of hemp-derived products in the United States, the government legalized CBD derived from hemp that contains no more than 0.3% THC by dry...
Need a reliable, crowd-sourced HR-MS database for screening Novel Psychoactive Substances (NPS)? by Pierre Negri | Aug 8, 2021 | Data processing, Forensic, QTOF, SCIEX information, SCIEX OS software, Toxicology, ZenoTOF 7600 systemThe recent influx of novel psychoactive substances (NPS) into the recreational drug market has posed a serious burden to public health. The availability of these substances through the Internet has contributed to the widespread of NPS globally, raising great concern...
Looking for an educational podcast on forensic toxicology? by Pierre Negri | Aug 8, 2021 | Forensic, Results, SCIEX information, ToxicologyListen to the Toxpod, an informative podcast about the many facets of the field of forensic toxicology created by Tim Scott and Peter Stockham, two forensic toxicologists working for the South Australian government. Produced by Forensic Science South Australia and the...
Stay informed on the latest novel psychoactive substances (NPS) flooding the US drug market by Pierre Negri | Aug 8, 2021 | Forensic, QTOF, QTRAP / Triple Quad, Results, SCIEX information, Toxicology, ZenoTOF 7600 systemEach year, the Drug Enforcement Administration (DEA) Special Testing and Research Laboratory publishes an Emerging Threat Report. The data contained in the report is updated quarterly and represents a snapshot of the drug evidence seized and analyzed by the DEA in the...
Analysis of chiral amphetamines using differential mobility separation (DMS) by Pierre Negri | Aug 7, 2021 | Data acquisition, Differential Mobility Separation (DMS), SCIEX information, TechnologyMany compounds are challenging to analyze because they are isomers (have the same m/z) and also sometimes have the same HPLC retention time. And to make it even more complicated, sometimes there are two chiral forms that have different functions in biology, making it...
Separating cyclosporin isomers using differential mobility separation (DMS) by Pierre Negri | Aug 7, 2021 | Data acquisition, Differential Mobility Separation (DMS), SCIEX information, TechnologyCyclosporin A (CsA) has been a very successful immunosuppressant for preventing organ transplant rejection. It is a large cyclic peptide (11 residues, ~1200 Da) and there are numerous modifications of this drug, some of which are isomers. The challenge of analyzing...