GEN-MKT-18-7897-A
Aug 23, 2016 | Biopharma, Blogs | 0 comments
At ASMS this year, the newest version of BioPharmaView Software was released. This software simplifies the processing of biotherapeutic data for characterization and comparability which can dramatically improve your productivity. BioPharmaView 2.0 Software accelerates characterization and comparability studies and simplifies reporting, so you can make better decisions, faster.Try it today >
Everything You Need in One ViewGetting started with BioPharmaView software is easy. From the main window, you can input your assay information and save your batch processing parameters. You can also define the biotherapeutic sequence and choose from common post-translational modifications, or easily add custom modifications of interest.
Compare it and Share itWhen it comes time to report your results, BioPharmaView software provides you with comprehensive reports in multiple output formats. You’ll be able to quickly show the products that passed or failed your custom flagging criteria, and easily transfer your processed data export to electronic notebook applications.
Quick Look Intact Mass Comparability is Now a RealityThe hardest part of Intact Mass Analysis is processing the data and comparing biologic product characteristics. BioPharmaView Software makes it easy with one click batch processing, protein form matching, and automated ratio calculations for post translational modifications, including glycosylation. The multi-pane view in the main window allows you to see the processed and raw data from multiple samples side by side, so you can be confident about your comparability conclusions.
No Fear of Antibody Drug ConjugatesIntact analysis of antibody-drug conjugates (ADCs) can be challenging because of the size and complexity of the molecules. There’s no need to worry about your ADCs with automated drug-antibody ratio (DAR) calculation and visualization, as well as a simplified—yet highly accurate—view of protein deconvolution in BioPharmaView Software. Comparing ADC products is much easier when you can see drug load and DAR across multiple samples, so you’ll be clear on just what you’ve got—and how much.
Peptide Maps in a FlashComparison of peptide sequences across samples is much faster and easier than before in BioPharmaView Software. Everything you need to see for peptide map comparability is available in one view: from comprehensive sequence coverage and PTM ratios, to the raw MS/MS data you need to see to confirm modifications, BioPharmaView Software provides an easy to use dashboard for Peptide Mapping. At a glance, you can compare peptides, PTMs, PTM ratios and disulfide bond localization.
Low Level Modifications Can’t Hide from SWATH® AcquisitionWhen performing Peptide Mapping of biotherapeutics, you have to determine where post-translational modifications are. Using SWATH Acquisition and BioPharmaView Software processing, you can detect low level modifications—as well as confirm them in the high-resolution MS/MS spectra—all in a single run. Plus, automated calculation of PTM ratios means you can spend more time understanding your data, and less time crunching the numbers.
Where are the Disulfide Bonds?Localizing disulfide bonds is no easy task. But the algorithms in BioPharmaView software make quick work of defining the bond locations and presenting the high-resolution, annotated MS/MS spectra for confirmation.
Still not convinced to try it? Watch this video >Try it today >Or buy it today > Did you know there’s now a way you can upgrade/update your software as soon as new versions become available? Get the most from your solutions and troubleshooting tips and maximize the full potential of your lab >
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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