GEN-MKT-18-7897-A
Oct 12, 2016 | Blogs, Environmental / Industrial | 0 comments
What happens when you up the sensitivity and lower detection limits on influent and effluent sewage tests? For starters, low levels of illegal drugs in samples begin to emerge. This is what researchers discovered when they combined the power of LC-MS/MS with the Scheduled MRM™ algorithm using large volume injection techniques on a QTRAP® 5500 system. Limits of Quantitation (LOQ) was the word in this application note, as sample results following the “The Street Parade Zurich,” dipped well into the low ng/L range eliminating the need for multi-period experiments.Download Compendium >
Tests like these go beyond standard surveys such as, “Monitoring the Future 2015 Results,” from the National Institute on Drug Abuse. While helpful in reporting the number of people who have tried or currently use illegal drugs, the results are not scientifically adequate. Tests such as the ones reported in this tech note can lead to better process controls at wastewater treatment plants, therefore lessening environmental impacts.
The Science behind Influent Wastewater Drug TestingUsing a completely redesigned LC method, a core-shell LC column was used to test influent water samples around the timing of the parade. This tech note is a must read for anyone who wants to learn how expanded column dimension allowed for large volume direction injection minus the breakthrough of polar compounds like morphine. It is just one of the research applications in this year’s Environmental Compendium, conveniently available for download. From pesticides to PPCP’s, unknown screenings, perfluoroalkyl acids, explosives, and flame retardants we not only give you data but explain the methods and instruments used to obtain the results so your lab can improve your discoveries.
Get more than you asked for when you download the SCIEX Environmental Compendium. Want to learn more about the QTRAP 5500? Visit our mass spectrometry products page today.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
CE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
At SCIEX, innovation doesn’t stop at instruments; it extends to how you interact with your LC-MS/MS or CE systems every day. That’s why we’re excited to introduce the SCIEX Now spring 2026 improvements: a set of meaningful enhancements shaped directly by your feedback.
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