GEN-MKT-18-7897-A
Nov 15, 2016 | Blogs, Life Science Research, Proteomics | 0 comments
The Stoller Biomarker Discovery Center, developed in partnership with SCIEX, was created to develop new omics technologies for biomarker research to understand the root cause of diseases such as cancer, cardiovascular disease, and autoimmune diseases. We initially announced our collaboration with the University of Manchester back in October 2015.
The Centre was officially opened at an event attended by Professor Dame Nancy Rothwell, President and Vice-Chancellor of The University of Manchester, Sir Norman Stoller and trustees of the Stoller Charitable Trust, Dan Daniel, Executive Vice President of Danaher and Jean-Paul MangeollePresident of SCIEX, with a ceremony during the Stoller Biomarker Discovery Centre Symposium. The event featured leading speakers from around the globe who shared their latest research on biomarker discovery and development, and included pioneers within the proteomics field such as Dr. Leroy Hood, Dr. Leigh Anderson, and Professor Jennifer Van Eyk.
Professor Rothwell said: “Manchester has become a major hub for precision medicine and proteomics and we are very grateful to the funders who have backed the cutting-edge work that is carried out by our scientists.”
“As a result of their generosity, The Stoller Biomarker Discovery Centre will start work on addressing some of the biggest issues in medicine in an environment where these discoveries can move quickly into utilization to improve people’s lives.”
The Stoller Biomarker Centre is located at CityLabs Manchester, a growing biomedical science hub, and adjacent to the Central Manchester University Hospitals, National Health Service (NHS) Foundation Trust and The University of Manchester. The new Centre houses a large suite of high-end SCIEX mass spectrometers for targeted next-generation proteomics, including TripleTOF® 6600 Systems for SWATH® Acquisition, QTRAP® 6500+ Systems, and the SCIEX Lipidyzer™ Platform. The University of Manchester has also invested in SCIEX nanoLC™ 400 liquid chromatography systems and automated sample preparation components (Beckman Coulter’s Biomek NXP Laboratory Automated Workstation) for the Centre.
“SCIEX mission of innovating integrated, reliable analytical tools to enable scientific discoveries that ultimately lead to better health care, enables our customers to advance precision medicine with scale and speed like never before,” states Jean-Paul Mangeolle, President of SCIEX. “And it takes more than providing great instruments to be part of a movement as important as Precision Medicine; it takes strong collaborations with researchers, partnerships with industry leaders and teamwork with our colleagues at other Danaher Life Science companies, to establish and deploy the most comprehensive proteomics solutions.”
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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