Stoller Biomarker Discovery Centre, Addressing Some of the Biggest Issues in Medicine

Nov 15, 2016 | Blogs, Life Science Research, Proteomics | 0 comments


The Stoller Biomarker Discovery Center, developed in partnership with SCIEX, was created to develop new omics technologies for biomarker research to understand the root cause of diseases such as cancer, cardiovascular disease, and autoimmune diseases. We initially announced our collaboration with the University of Manchester back in October 2015. 



The Centre was officially opened at an event attended by Professor Dame Nancy Rothwell, President and Vice-Chancellor of The University of Manchester, Sir Norman Stoller and trustees of the Stoller Charitable Trust, Dan Daniel, Executive Vice President of Danaher and Jean-Paul MangeollePresident of SCIEXwith a ceremony during the Stoller Biomarker Discovery Centre Symposium. The event featured leading speakers from around the globe who shared their latest research on biomarker discovery and development, and included pioneers within the proteomics field such as Dr. Leroy Hood, Dr. Leigh Anderson, and Professor Jennifer Van Eyk.

Professor Rothwell said: “Manchester has become a major hub for precision medicine and proteomics and we are very grateful to the funders who have backed the cutting-edge work that is carried out by our scientists.”

“As a result of their generosity, The Stoller Biomarker Discovery Centre will start work on addressing some of the biggest issues in medicine in an environment where these discoveries can move quickly into utilization to improve people’s lives.”

The Stoller Biomarker Centre is located at CityLabs Manchester, a growing biomedical science hub, and adjacent to the Central Manchester University Hospitals, National Health Service (NHS) Foundation Trust and The University of Manchester. The new Centre houses a large suite of high-end SCIEX mass spectrometers for targeted next-generation proteomics, including TripleTOF® 6600 Systems for SWATH® AcquisitionQTRAP® 6500+ Systems, and the SCIEX Lipidyzer™ Platform. The University of Manchester has also invested in SCIEX nanoLC™ 400 liquid chromatography systems and automated sample preparation components (Beckman Coulter’s Biomek NXP Laboratory Automated Workstation) for the Centre.

“SCIEX mission of innovating integrated, reliable analytical tools to enable scientific discoveries that ultimately lead to better health care, enables our customers to advance precision medicine with scale and speed like never before,” states Jean-Paul Mangeolle, President of SCIEX. “And it takes more than providing great instruments to be part of a movement as important as Precision Medicine; it takes strong collaborations with researchers, partnerships with industry leaders and teamwork with our colleagues at other Danaher Life Science companies, to establish and deploy the most comprehensive proteomics solutions.”

ProteinPilot phosphopeptide library and DIA-NN

I have prepared a spectral library for a phosphopeptide enriched sample and I am generating my SWATH samples from similarly enriched samples. The problem is that when I use DIA-NN for the retention time alignment and quant, it doesn’t recognise the terminology of the spectral library annotated by ProteinPilot. DIA-NN recognises Unimod:21 for phosphorylation, but PP uses phospho(Tyr) etc. Other than changing the data dictionary to get around the mismatch, anyone have any suggestions for how I might resolve this? Thank you, Roz

Current proteomics software compatibility for ZenoTOF 7600 system

Below is a summary of various other software packages that are useful for processing proteomics data from the ZenoTOF 7600 system.  Note this list is not comprehensive and only covers the tools we have lightly tested to date. Acquisition Type Software Files needed...

Sequential processing of multiple data-files in ProteinPilot

I would like to use ProteinPilot 5.0.2 to process data-sets containing 16 wiff files acquired from fractionated peptides on a 6600 TripleTOF. A Precision T7910 workstation struggles to process four files in parallel and I would like to be able to queue sequential processing of individual files overnight. I currently use the ‘LC ‘ tab to load and process individual data-files but this leads to parallel processing. Is it possible to generate 16 .group files sequentially?

Posted by


Submit a Comment