Turning up the Speed on Forensic Toxicology Screening and Quantitation

Mar 3, 2017 | Blogs, Forensic | 0 comments

Working in a forensic lab means technicians want super high-quality data in ultra-fast time. Yet, how do you go about detecting an unlimited number of analytes without re-injecting the sample all while new targeted compounds are being added to the screened panel? In the following application note, “Ultra-Fast Forensic Toxicological Screening and Quantitation in Under 3 Minutes Using SCIEX X500R QTOF System and SCIEX OS 1.0 Software,” researchers set out to achieve a fast method that could detect an unlimited number of analytes with all information afforded mass accuracy, LC retention time, and MS/MS spectral library matching.

Perhaps you have encountered a situation in which an aging sample contains compounds, yet they have degraded and are no longer detectable. Moments like these were front and center on the minds of our researchers as they went about their analysis and knowing that high-speed data processing and straightforward sample preparation are key to a lab’s productivity without the need to reanalyze, they got to work. Using the X500R system with its Time of Flight (TOF) technology, they found that modern QTOF systems provide the capability of switching between MS and MS/MS scans instantly, enabling rapid obtainments of structural information.

Want to know more? Discover how the researchers optimized conditions and extended LC runtime using different columns than previous methods, for better retention of polar species. Source parameters, system settings, chromatograms, and identifying results are all depicted within this application note.  However, the biggest take away our researchers want to convey is that SWATH® Acquisition makes it, so all detectable data is captured at once, so there is no need to reanalyze the sample down the line. 


For research use only. Not for use in diagnostic procedures.

Telling the PFAS story with pine needles

As an ever-expanding group of chemicals, per- and polyfluoroalkyl substances (PFAS) require novel techniques to monitor their current and historical presence in the environment. Concerns over exposure to PFAS chemicals continue to grow, with some having known toxic characteristics and the potential effects of others remaining unknown.1 In addition, while PFAS are one of the most persistent synthetic chemicals to date, most of them hardly degrade in the environment.2 So, how long do traces of PFAS last in our environment? Two tools used to help answer this question are active samplers and passive samplers.

Back to the new basics: Part 3 | LC vs. LC-MS and what it means for your lab

In this final installment of our “Back to the new basics” series, we take one more look at analytical techniques and best practices in the lab, and opportunities to improve efficiency. Here, we explore the basic principles of high-performance liquid chromatography (LC) and liquid chromatography mass spectrometry (LC-MS), and how these techniques can affect a lab’s efficiency and productivity.

Meat vs plant based. What is the best option?

As we become more conscious about the planet, healthier lifestyles and our duty to protect the environment, attitudes and behaviours are shifting when it comes to food consumption.

Posted by


Submit a Comment