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Jun 20, 2019 | Blogs, Food / Beverage | 0 comments
We know that antibiotics used to treat livestock can end up in the food we eat. Routine food testing labs are essential for detecting compounds, like these, that can be dangerous to our health. Antibiotic residues include both parent molecules and metabolites left over in the animal’s body after treatment. They are a class of compound that causes a lot of concern. Using antibiotics in livestock, and its alarming connection to antibiotic-resistant bacteria is not a new topic. Antibiotic resistance is known as a global threat to human health. Many countries have ongoing efforts to both stop the overuse of antibiotics and to keep track of the effect of antibiotic-resistant bacteria on the population.
Antibiotic residues in food that comes from animals are a complex threat. Antibiotics are used to promote growth and to stop microbial infections in livestock. The more times the bacteria get a non-lethal dose of the antibiotic, the more likely they are to become immune to that antibiotic. A similar thing happens when humans consume food products from the treated livestock that contain residues of these antibiotics. The exposure can increase the chance of antibiotic resistance, transfer resistant bacteria to humans, and cause problems in people with hypersensitivity to the antibiotic. Hundreds of thousands of people die globally from infections caused by antibiotic-resistant bacteria each year.
Many countries have set tolerance limits (or maximum residue limits) for antibiotic residues in food products. Keeping human exposure below the maximum residue limits is the main goal of routine food testing. It is important to accurately monitor these levels for the sake of public safety. Robust and reliable analytical methods are required. Detecting multiple antibiotics with a single analytical method increases the efficiency of the monitoring. Methods that meet the performance levels required by regulatory agencies are also essential.
The SCIEX Solution for Routine Testing LabsLC-MS/MS technology is a valuable tool to help fight the threat of antibiotic resistance. A complete analytical solution includes hardware, software, and a proven method to produce reliable LC-MS/MS data. An ideal method achieves the selectivity and sensitivity required to meet regulatory requirements. It also minimizes sample preparation and detects multiple analytes for increased throughput.
Find out how the SCIEX Triple Quad™ 3500 System with Turbo V™ source and MultiQuant™ software can help reduce exposure to antibiotic residues in our food. Complete the form on your right to access practical applications performed on the TripleQuad 3500 System including a method to analyze chloramphenicol and tetracyclines in honey, milk, meat, and shrimp.
It is no secret that (bio)pharmaceutical research and development is complex, both scientific and regulatory processes. Here is an overview of just some of the ways SCIEX is working to support these challenges.
In a recent webinar, available on demand, scientists Luiza Chrojan and Ryan Hylands from Pharmaron, provided insights into the deployment of capillary gel electrophoresis (CGE) within cell and gene therapy. Luiza and Ryan shared purity data on plasmids used for adeno-associated virus (AAV) manufacturing and data on AAV genome integrity, viral protein (VP) purity and VP ratios using the BioPhase 8800 system.
Last year, Technology Networks hosted two webinars that featured groundbreaking research utilizing SWATH DIA (data-independent acquisition) for exposomics and metabolomics. Researchers Dr. Vinicius Verri Hernandes from the University of Vienna and Dr. Cristina Balcells from Imperial College London (ICL) demonstrated how a DIA approach can be successfully implemented in small molecule analysis using the ZenoTOF 7600 system. Their innovative approaches highlight the potential of SWATH DIA to enhance the detection and analysis of chemical exposures and metabolites, paving the way for new insights into environmental health and disease mechanisms.
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