GEN-MKT-18-7897-A
Jun 20, 2019 | Blogs, Food / Beverage | 0 comments
We know that antibiotics used to treat livestock can end up in the food we eat. Routine food testing labs are essential for detecting compounds, like these, that can be dangerous to our health. Antibiotic residues include both parent molecules and metabolites left over in the animal’s body after treatment. They are a class of compound that causes a lot of concern. Using antibiotics in livestock, and its alarming connection to antibiotic-resistant bacteria is not a new topic. Antibiotic resistance is known as a global threat to human health. Many countries have ongoing efforts to both stop the overuse of antibiotics and to keep track of the effect of antibiotic-resistant bacteria on the population.
Antibiotic residues in food that comes from animals are a complex threat. Antibiotics are used to promote growth and to stop microbial infections in livestock. The more times the bacteria get a non-lethal dose of the antibiotic, the more likely they are to become immune to that antibiotic. A similar thing happens when humans consume food products from the treated livestock that contain residues of these antibiotics. The exposure can increase the chance of antibiotic resistance, transfer resistant bacteria to humans, and cause problems in people with hypersensitivity to the antibiotic. Hundreds of thousands of people die globally from infections caused by antibiotic-resistant bacteria each year.
Many countries have set tolerance limits (or maximum residue limits) for antibiotic residues in food products. Keeping human exposure below the maximum residue limits is the main goal of routine food testing. It is important to accurately monitor these levels for the sake of public safety. Robust and reliable analytical methods are required. Detecting multiple antibiotics with a single analytical method increases the efficiency of the monitoring. Methods that meet the performance levels required by regulatory agencies are also essential.
The SCIEX Solution for Routine Testing LabsLC-MS/MS technology is a valuable tool to help fight the threat of antibiotic resistance. A complete analytical solution includes hardware, software, and a proven method to produce reliable LC-MS/MS data. An ideal method achieves the selectivity and sensitivity required to meet regulatory requirements. It also minimizes sample preparation and detects multiple analytes for increased throughput.
Find out how the SCIEX Triple Quad™ 3500 System with Turbo V™ source and MultiQuant™ software can help reduce exposure to antibiotic residues in our food. Complete the form on your right to access practical applications performed on the TripleQuad 3500 System including a method to analyze chloramphenicol and tetracyclines in honey, milk, meat, and shrimp.
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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