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Is Your Beverage Truly 100% Fruit Juice?

Dec 16, 2016 | Blogs, Food / Beverage | 0 comments

There is nothing like the flavor of fruit juice whether freshly squeezed or made from concentrate to clench your thirst, except when it’s not 100 percent juice after all. As the following tech note, “Authenticity Assessment of Fruit Juices using LC-MS/MS and Metabolomic Data Processing,” (pgs.135-141) points out, such substances have become a likely target for fraud and adultery practice even though certain legislation measures dictate authenticity parameters.

Why should we care? Consumers love to buy fruit juice. In a report by New Scientist, Britain sells more than 800 million pounds per year, while the U.S. holds it stakes at $12 billion or 7.5 billion pounds. Important numbers since 16 out of 21 brands of orange juice sold in Britain contained false ingredients such as beet sugar.Download The Food Compendium >

The problem with existing methods, however, is they are limited to targeted approaches useful when testing one or a handful of adulterations and researchers need to cast a wider net to keep up with the numerous compounds being added to the products. Using LC-MS/MS techniques with the QTRAP® and TripleTOF® systems researchers were able to capture non-targeted results for proof of authenticity. Included in the application note are details right down to where the juices were purchased to sample prep and results.

Why download the compendium? Gain access to almost 200 pages and 18 application methods that respond to real world problems like the ones discussed here. For example, how will you bring these solutions into your lab and improve upon current testing methods? Branch out with new and improved methods you can only find here. It’s just one way you can help prevent the food fraudulence. 

Questions and answers to help improve your mycotoxin analysis

During a recent webinar I shared method details for mycotoxin analysis on the SCIEX 7500 system. In this blog i will share the Q&A for the submitted questions that we did not have chance to answer during the live webinar.

A 2-fold revolution: MS approaches for the bioanalysis of oligonucleotide therapeutics

In 1998, the US Food and Drug Administration (FDA) approved fomivirsen as the first therapeutic oligonucleotide therapeutic. This approval marked a revolution of mechanism of action discovered decades before finally coming to fruition. Since then, the landscape of chemical modifications of oligonucleotides, conjugations and formulations has evolved tremendously, contributing to improvements in stability, efficacy and safety. Today, more than a dozen antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) drugs are on the market, most of which are designated as orphan drugs for treating rare genetic diseases.

Is “right first time, every time” a pipedream for metabolite identification by LC-MS?

If we lived in an ideal world, it would be possible to unambiguously identify metabolites using a single analytical experiment. This analytical technique would need to be efficient and easily generate the information needed from a routine assay that is also robust, enabling confident decision-making during drug discovery.

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